Pharmacodynamic interaction

Last revision: 2015-11-30 06:57 classification: efficacy 0 people commented that one drug changed the pharmacological effect of another drug, but it had no obvious effect on the blood concentration, but mainly affected the effects of drugs and receptors Specifically, it can be divided into the following forms: (1) competition with receptor binding: for example, atropinian anti-m-choline receptor agonist, propranololian anti beta adrenergic receptor agonist, phentolamine anti alpha adrenergic receptor agonist, sodium naloxone anti morphine, etc (2) Sensitization phenomenon: the sensitization phenomenon is that one drug can make the tissue or receptor more sensitive to another drug For example, potassium excreting diuretics can reduce blood potassium, which makes the heart sensitive to cardiac glycosides and prone to arrhythmia It can be caused by reserpine or guanethidine Kidney I: adenosine receptor is similar to the phenomenon of denervation hypersensitivity, so that adrenaline like drugs with direct effect, such as noradrenaline The pressor effect of adrenaline was enhanced (3) The effect of neurotransmitters: the combination of enzyme inhibitors (such as paglin, etc.) with ephedrine, m-hydroxyamine and other drugs can release a large amount of noradrenalin from the storage site, resulting in the rise of blood pressure, even high M-pressure crisis Monoamine oxidase inhibitor combined with tricyclic antidepressants and levodopa can also cause high risk (4) When two drugs with the same pharmacological effect are used together, their effects can be synergetic If they are not used less, they may be poisoned If atropine and chlorpromazine are used together, it can cause the symptom of over low cholinergic nerve function; if aminoglycoside antibiotics are used together with magnesium sulfate, it can strengthen the respiratory paralysis caused by magnesium sulfate; if aminoglycoside antibiotics are combined with each other, the antibacterial effect is added, but the ear / kidney mold is also increased Pharmacokinetics of traditional Chinese medicine, Science Press, January 2013, page 122