Pharmaceutical grade tromethamine 1kg TRIS spot pharmacopeia standard test

Pharmaceutical grade tromethamine 1kg TRIS spot pharmacopoeia standard test [C4H11NO3=121.
14] This product is 2-amino-2-hydroxymethyl-1,3-propanediol
.

According to the calculation of dry products, the inclusion of C4H11NO3 shall not be less than 99.
0%.

Properties This product is white crystal; Odorless, slightly sweet and bitter
.

This product is easily soluble in water and dissolved
in ethanol.

Melting point The melting point of this product (appendix 13 page) is 168 ~ 172 °C
.

Identification (1) Take potassium periodate solution (0.
05→10) 2ml, add 1 drop of nitric acid, mix well, add 5mg of this product, shake, add 5 drops of silver nitrate test solution, that is, appear white and cloudy
.

(2) Take 0.
2g of this product, add 1ml of water to dissolve, add 1ml of saturated solution and 2 drops of glacial acetic acid, that is, yellow
.

Check the alkalinity take 1g of this product, add 20ml of water to dissolve, and determine according to law (page 33 of Appendix), the pH value should be 10.
0 ~ 11.
5
.

Nickel salt Take 1g of this product, add 10ml of water to dissolve, add 1ml of ammonia test solution and 2ml of butadione oxime test solution, let it sit for 10 minutes, such as color development, with standard nickel solution (precision weigh nickel ammonium sulfate 0.
6730g, placed in a 1000ml measuring bottle, add an appropriate amount of water to dissolve and dilute to the scale, shake well
.

Take 10ml of precision, put it in a 100ml measuring bottle, dilute it with water to the scale, shake well) 1.
5ml compared with the control made by the same method, not deeper (0.
0015%)
.