Pharmaceutical grade sodium polyacrylate imported NP700 model

Polyacrylic resin II.
Jubingxisuan Shuzhi II.
Polyacrylic Resin II.
This product is copolymerized
with methacrylic acid and methyl methacrylate in a ratio of 1:1.

【Properties】This product is a white strip or powder, which is easy to agglomerate
in ethanol.

This product (if the strip is broken into a length of about 1 cm, the powder is not ground) is dissolved in warm ethanol within 1 hour and is insoluble
in water.

Acid value Take about 0.
5g of this product, precision weighing, placed in a 250ml Erlenmeyer flask, add 75% neutral ethanol (phenolphthalein indicator liquid is neutral) 25ml, micro-temperature to dissolve, let cool, precision drop sodium hydroxide titration solution (0.
1mol / L) 15ml, add sodium chloride 5g with water 10ml, with sodium hydroxide titration solution (0.
1mol / L) continue to titrate until pink for 30 seconds without fading
.

The acid value of this product (general 0713), calculated according to the dry product, should be 300 ~ 330
.

【Identification】 The infrared light absorption pattern of this product should be consistent with the pattern of the control product (General Principle 0402
).

【Inspection】Viscosity Take 6.
0g of this product, add 100ml of ethanol, dissolve it at a slight temperature, use a rotary viscometer, and determine according to law (general 0633 third method), the dynamic viscosity at 25 ° C shall not exceed 50mPa・s
.

Acidity Take 3.
0g of this product, add 100ml of 75% ethanol with a pH of about 7, dissolve at a low temperature, let it cool, and determine according to law (general 0631), the pH value should be 4.
0 ~ 6.
0
.

Residual monomers are determined
by high performance liquid chromatography (General 0512).

Chromatographic conditions and system suitability test With octadecyl silane-bonded silica gel as the filler, methanol-water (pH adjusted with phosphoric acid to 2.
0) (20:80) as the mobile phase, the detection wavelength is 202 nm
.

The degree of separation between the peak of methacrylate, the peak of methyl methacrylate and the adjacent peak of impurities should meet the requirements
.

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