Pharmaceutical-grade sodium carboxymethyl starch acts as a disintegrant and bulking agent

Use and action of pharmaceutical grade sodium carboxymethyl starch starch starch white powder
.
Odorless and tasteless
.
Dissolved in water at room temperature to form a colloidal solution
.
It is easily soluble in water under stirring, and can also be moistened with ethanol before being added to water
.
Making the aqueous solution acidic produces free acids that are insoluble in water, and the viscosity is reduced
.
It is relatively stable
to alkali.
The addition of metal salts forms a variety of metal salts that are insoluble in water, so it is not suitable for strongly acidic foods
.
It should not be in long-term contact
with metal during manufacturing.
If the aqueous solution is heated above 80 °C for a long time, the viscosity is reduced
.
The aqueous solution of this product will be partially decomposed by bacteria in the atmosphere, reducing the viscosity
.
It is more difficult to hydrolyze
than ordinary starch.
Insoluble in methanol, ethanol and other organic solvents
.
pH 6.
7~7.
0
of 1% aqueous solution.
The aqueous solution is more stable in alkali and worse
in acid.
[Content determination] take 1g of this product, put it in an Erlenmeyer flask, add 20ml of 80% ethanol, stir and filter; Repeat until the filtrate is checked for chloride with silver nitrate test solution
.
take the filter residue at 105 °C to dry to constant weight, take about 0.
45g, weigh it accurately, put it in a 150ml Erlenmeyer flask, add 50ml of glacial acetic acid, shake well, heat and reflux on a boiling water bath for 2 hours, cool, move to a 100ml beaker, wash the Erlenmeyer flask with glacial acetic acid 3 times, 5ml each time, the washing solution is incorporated into the beaker, according to the potentiometric titration method (General rule 0701), titrated with perchloric acid titration solution (0.
1mol/L), and the results of the titration are corrected
with a blank test.
Each 1 ml of perchloric acid titration solution (0.
1 mol/L) is equivalent to 2.
299 mg of Na
.
Calculated according to the dried product washed by 80% ethanol solution, it should comply with the provisions of
the schedule.
Sodium carboxymethyl starch, also known as carboxymethyl starch, is an anionic starch ether with the chemical formula [C10H19O8Na]n, white or yellow powder, is an electrolyte soluble in cold water
.
It is a kind of modified starch, which belongs to ether starch and is a water-soluble anionic polymer compound
.
It is odorless, non-toxic, not easy to mildew, soluble in water when the degree of substitution is greater than 0.
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