Pharmaceutical Grade Polysorbate 80 Tween 80 Emulsifying Excipients

Pharmaceutical grade polysorbate 80 Tween 80 emulsification excipients Tan
.

【Properties】This product is light yellow to orange-yellow viscous liquid
.

This product is easily soluble in water, ethanol, methanol or ethyl acetate, and very slightly soluble in mineral oil
.

Relative density The relative density of this product (general rule 0601) is 1.
06 to 1.
09
.

Viscosity The kinematic viscosity of this product (general rule 0633 method) is 350~550mm2/s at 25°C (the inner diameter of the capillary is 2.
0~2.
5mm)
.

Take 10g of this product for acid value, accurately weigh it, put it in a 250ml conical flask, add 50ml of neutral ethanol (neutral to phenolphthalein indicator solution) to dissolve, attach a reflux condenser to boil for 10 minutes, let it cool, add phenolphthalein indicator solution 5 drops, titrated with sodium hydroxide titration solution (0.
1mol/L), the acid value (general rule 0713) should not exceed 2.
0
.

　　Hydroxyl Value The hydroxyl value of this product (general rule 0713) is 65-80
.

　　Iodine value The iodine value of this product (general rule 0713) is 18 to 24
.

　　Peroxide value The peroxide value of this product (general rule 0713) shall not exceed 10
.

Tween 80 is an emulsifier
.

Tween 80 refers to polysorbate-80, a powerful emulsifier that disperses other substances evenly in solution
.

Polyoxyethylene sorbitan monooleate, referred to as polysorbate-80, easily soluble in water, ethanol, vegetable oil, ethyl acetate, methanol, toluene, insoluble in mineral oil
.

Emulsifiers are a class of substances that enable a mixture of two or more immiscible components to form a stable emulsion
.

Its working principle is that in the emulsification process, the dispersed phase is dispersed in the continuous phase in the form of droplets (micron scale), and the emulsifier reduces the interfacial tension of each component in the mixed system and forms a firmer film on the surface of the droplet.
Or due to the charge given by the emulsifier, an electric double layer is formed on the surface of the droplets, preventing the droplets from agglomerating with each other, and maintaining a uniform emulsion
.

From a phase point of view, emulsions are still heterogeneous systems
.

The dispersed phase in the emulsion can be water phase or oil phase, most of which are oil phase; the continuous phase can be oil phase or water phase, most of which are water phase
.

Emulsifier is a surfactant with hydrophilic and lipophilic groups in the molecule
.

In order to express the hydrophilicity or lipophilicity of the emulsifier, the hydrophilic-lipophilic balance value (HLB value) is usually used.
The lower the HLB value, the stronger the lipophilicity; on the contrary, the higher the HLB value, the stronger the hydrophilicity
.

The HLB value of various emulsifiers is different.
In order to obtain a stable emulsion, an appropriate emulsifier must be selected
.