Pharmaceutical-grade menthol uses flavor and fragrance

Medicinal grade menthol uses flavor corrector and fragrance menthol is a chemical agent, menthol is extracted from the leaves and stems of peppermint, white crystals, molecular formula C10H20O, is the main component
of peppermint and peppermint essential oils.
In the world, China and Brazil are the main Dutch producers, and the annual output of peppermint oil reaches 2000-3000t
.
Both menthol and racemic menthol can be used as toothpaste; Perfume; Excipients
for beverages and confectionery, etc.
It is used as a medicine in medicine and acts on the skin
.
1.
Both menthol and racemic menthol are used as excipients in toothpaste
, perfumes, beverages and candies.
It is used as a stimulant in medicine, acting on the skin or mucous membranes, and has a cooling and itching effect; It can be taken internally as a carminative medicine for headache and inflammation of the nose, pharynx and larynx
.
Its esters are used in fragrances and medicines
.
In the world, China and Brazil are the main natural mint production gardens, and the annual output of peppermint oil has reached 2000-3000t
.
2.
Widely used in daily flavors, food flavors, tobacco flavors
.
Generally in chewing gum 1100mg/kg; 400mg/kg in candy; 130mg/kg in baked goods; ice cream 68mg/kg; 35mg/kg
in soft drinks.
3.
It has bactericidal and antiseptic effects
.
4.
Used as a special additive
for curative cosmetics.
For floral water, etc
.
It can also be used as a fragrance aid
for toothpaste, perfume, beverages and candy.
Used in the preparation of candy, beverages, spices and medicinal purposes [Identification] (1) take 1g of this product, add 20ml of sulfuric acid to dissolve, that is, orange-red, and after 24 hours, a colorless oil layer without menthol aroma (the difference from thymol)
is precipitated.
(2) take 50mg of this product, add 1ml of glacial acetic acid to dissolve, add 6 drops of sulfuric acid and 1 drop of nitric acid cold mixture, only light yellow (difference from thymol).

【Inspection】Related substances take an appropriate amount of this product, weigh it accurately, add absolute ethanol to dissolve and quantitatively dilute to make a solution containing about 50mg per 1ml, as a test solution; In addition, an appropriate amount of menthol reference substance was taken, accurately weighed, anhydrous ethanol was added to dissolve and quantitatively diluted to make a solution containing about 0.
5mg per 1ml as a reference solution
.
According to the chromatographic conditions under the content determination item, in which the column temperature is 110 °C, 1μl of the reference solution is injected into the gas chromatograph, the chromatogram is recorded, and the signal-to-noise ratio of the peak height of the principal component should be greater than 10; Then take 1μl of the test solution and 1μl of the reference solution, inject them into the gas chromatograph respectively, and record the chromatogram to 2 times
the retention time of the principal component peak.
If there are impurity peaks in the chromatogram of the test sample, the sum of the peak areas of each impurity shall not be greater than the main peak area of the reference solution (1.
0%)
.
Non-volatile matter take 2g of this product, put it in an evaporation dish that has been dried to constant weight, heat it on a water bath, so that after slow evaporation, dry to constant weight at 105 °C, and the residual residue shall not exceed 1mg
.
Heavy metals and harmful elements According to the determination method of lead, cadmium, arsenic, mercury and copper (General 2321), the lead content shall not exceed 0.
0005%, cadmium shall not exceed 0.
00003%, arsenic shall not exceed 0.
0002%, mercury shall not exceed 0.
00002%, copper shall not exceed 0.
002%.

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