Pharmaceutical grade low substituted hypromellose acts as a disintegrant and filler

Pharmaceutical grade low substituted hypromellose action disintegrant and filler low substituted hypromellose is a low substituted hydroxypropyl cellulose ether, is a multi-purpose non-ionic cellulose derivative, mainly used as solid preparation disintegration and binder, because its powder has a large surface area and porosity, so it can quickly absorb water and expand, used in tablets, so that the tablet rapid disintegration, at the same time its rough structure and drugs and particles between the large inlay, can significantly improve the tablet hardness, while not affecting disintegration, Thereby accelerating the dissolution of the drug and improving bioavailability
.
The dosage of this product is generally about 2-5%, which can be used in the production of tablets for wet granulation, and can also be added or added internally and externally at the same time for better
effect.
When used as a tablet binder, the general dosage of wet granulation is 2-20%.

This product can be used as an emulsifier, stabilizer, suspension and thickener
in food additives.
Low-substituted hydroxyprocellulose is widely
used in oral solid dosages.
Mainly used as a tablet disintegrant, or wet granulation binder
.
It can also be used in
rapid disintegrating tablets prepared from direct tableting.
Low-substituted hydroxyprocellulose has many grades
such as different particle sizes and different degrees of substitution.
LH-11 is a medium substitution with the largest particle size, and is mainly used as a disintegrant
to prevent tablet top-cracking and direct tablet compression.
LH-21 is mainly used as an adhesive and disintegrant
for wet granulated tablets.
LH-31 has smaller particles, is mainly used for extrusion granulation, and is easier to pass through the screen due to its small particle size
.
The lower substitution of LH-22 and LH-32 can be used
without greater adhesion.
When greater adhesion is required, the higher substitution LH-20 and LH-30
can be used.
Generally, the concentration of low-substituted hydroxypropanol in the prescription is 5~25%.

This product is a low substituted hydroxypropyl cellulose ether, is a multi-purpose non-ionic cellulose derivative, mainly used as solid preparation disintegration and binder, because its powder has a large surface area and porosity, so can quickly absorb water and expand, used in tablets, so that the tablet rapid disintegration, at the same time its rough structure and drugs and particles between the large inlay, can significantly improve the tablet hardness, while not affecting disintegration, thereby accelerating the dissolution of the drug, improve bioavailability
.
The dosage of this product is about 2-5% in k, which can be used in wet granulation in tablet production, and can also be added or added internally and externally at the same time for better
effect.
When used as a tablet binder, the general dosage of wet granulation is 2-20%.

This product can be used as an emulsifier, stabilizer, suspension and thickener
in food additives.
Low-substituted hydroxyprocellulose is widely
used in oral solid dosages.
Mainly used as a tablet disintegrant, or wet granulation binder
.
It can also be used in
rapid disintegrating tablets prepared from direct tableting.
【Content determination】Hydroxypropoxy take this product, according to methoxy, ethoxy and hydroxypropoxy determination method (General 0712).

If the second method (volume method) is used, take about 0.
1g of this product, accurately weigh, and measure according to law.

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