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Pfizer's lorlatinib receives FDA approval for first-line treatment of ALK-positive metastatic lung cancer

 Last Update: 2021-04-28
 Source: Internet
 Author: User

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Source: Immediate Medicine News

On March 3, Pfizer announced that the U.

Lorbrena’s expanded indications are based on the results of the pivotal phase 3 clinical trial CROWN, and the blinded independent central review (BICR) evaluation showed that in the previously untreated patient population, compared with crizotinib, the risk of progression or death Decrease by 72% (HR=0.

Lung cancer is the number one cause of cancer-related deaths around the world.

Lorbrena is a third-generation ALK tyrosine kinase inhibitor (TKI), specifically designed to inhibit the most common tumor mutations (resulting in resistance to current drugs) and to resolve brain metastases (a common site of ALK-positive NSCLC disease progression).

Note: The original text has been deleted

Note: This article aims to introduce the progress of medical and health research, not to recommend treatment options.

Reference materials:

[1] US FDA EXPANDS APPROVAL OF PFIZER'S LORBRENA® AS FIRST-LINE TREATMENT FOR ALK-POSITIVE METASTATIC LUNG CANCER.

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