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Today, Pfizer announced that the mRNA quadrivalent influenza vaccine jointly developed by the company and BioNTech has completed the first batch of adult volunteers in a phase 1 clinical trial
Conventional seasonal influenza vaccines are generally made by growing the virus in chicken eggs or mammalian cells and inactivating them into vaccines
Even if the vaccine strain is well matched with the circulating virus strain, the protection rate of the current seasonal vaccine against the circulating strain is usually 40% to 60%
The mRNA-based influenza vaccine design only requires the gene sequence of the virus
Reference materials:
[1] Pfizer Starts Study of mRNA-Based Next Generation Flu Vaccine Program.