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People with Behcet's disease are ten times more likely to be blind than the average person! Clinical vigilance!

 Last Update: 2022-10-03
 Source: Internet
 Author: User

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▎Clinical question: Are patients with Behcet's disease (BD) at higher risk of blindness and other eye-threatening ocular complications than the general population? Literature screenshot ▎ Study plan: This study conducted a population-based cohort study with data from the 2002-2017 National Health Insurance Service database, and included newly diagnosed patients with BD and non-BD control populations
matched by age and sex in a 1:5 ratio.

The study included 31,228 patients with BD and 156,140 control individuals
.

After 9.
39 years of follow-up, the incidence of blindness per 1000 people and years was 0.
24 in the BD group, 0.
02 in the control group, and the HR was 10.
73, and the 95% CI was 7.
10-16.
22
.

Among the secondary outcome measures, HR for cataract surgery was 2.
06, 95% CI 1.
98 to 2.
15, HR for glaucoma surgery was 5.
43, 95% CI 4.
57 to 6.
45, and retinal surgery HR was 2.
71 and 95% CI 2.
39 to 3.
07
.

The HR for developing uveitis was 6.
19, 95% CI 5.
83 to 6.
58
.

Because the incidence of uveitis is low in men but more severe than in women, the risk of blindness is higher in men than in women and is not proportional to
the incidence of uveitis.

At the same time, with the increasing age of BD diagnosis, the risk of uveitis and blindness decreases
.

▎ Conclusions and Outlook: In this large population-based cohort study, patients with BD had a 10.

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