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Pemetrexed is a commonly used antitumor drug, commonly used in the treatment of non-squamous non-small cell lung cancer and malignant pleural mesothelioma
Pemetrexed is a commonly used antitumor drug, commonly used in the treatment of non-squamous non-small cell lung cancer and malignant pleural mesothelioma
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Pemetrexed is a multi-target folate antagonist Pemetrexed is a multi-target folate antagonist
Platelet count ≥100000 cells/mm3
CrCl≥45 ml/min
Total bilirubin ≤ 1.
ALP, AST and ALT ≤ 3 times the upper limit of normal, or 5 times the upper limit of normal (considered when the tumor affects the liver)
ANC≥1500 cells/mm3
ANC≥1500 cells/mm3
ANC≥1500 cells/mm3Platelet count ≥100000 cells/mm3
Platelet count ≥100000 cells/mm3
Platelet count ≥100000 cells/mm3CrCl≥45 ml/min
CrCl≥45 ml/min
CrCl≥45 ml/minTotal bilirubin ≤ 1.
Total bilirubin ≤ 1.
Total bilirubin ≤ 1.
ALP, AST and ALT ≤ 3 times the upper limit of normal, or 5 times the upper limit of normal (considered when the tumor affects the liver)
ALP, AST and ALT ≤ 3 times the upper limit of normal value, or 5 times the upper limit of normal value (can be considered when the tumor affects the liver).CrCl: creatinine clearance
ALP: Alkaline Phosphatase
AST: aspartate aminotransferase
ALT: alanine aminotransferase
ANC: Absolute Neutrophil Count Absolute Value
ANC: Absolute Neutrophil Count Absolute Value
ANC: Absolute Neutrophil Count Absolute ValueCrCl: creatinine clearance
CrCl: creatinine clearance
CrCl: creatinine clearanceALP: Alkaline Phosphatase
ALP: Alkaline Phosphatase
ALP: Alkaline PhosphataseAST: aspartate aminotransferase
AST: aspartate aminotransferase
AST: aspartate aminotransferaseALT: alanine aminotransferase
ALT: alanine aminotransferase
ALT: alanine aminotransferasereferences:
references:1.
1.
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3.
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Kim YS, Sun JM, Ahn JS, Ahn MJ, Park K.
The optimal duration of vitamin supplementation prior to the first dose of pemetrexed in patients with non-small-cell lung cancer.
Lung Cancer.
2013;81(2):231 -235.
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Takagi Y, Hosomi Y, Sunami K, et al.
Aprospective study of shortened vitamin supplementation prior tocisplatin-pemetrexed therapy for non-small cell lung cancer.
Oncologist.
2014;19(11):1194-1199.
doi:10.
1634/ theoncologist.
2014-0221
Takagi Y, Hosomi Y, Sunami K, et al.
Aprospective study of shortened vitamin supplementation prior tocisplatin-pemetrexed therapy for non-small cell lung cancer.
Oncologist.
2014;19(11):1194-1199.
doi:10.
1634/ theoncologist.
2014-0221
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Schlei Z, Tan W, Faber MG, Chen H, Meagher A, Dy GK.
Safetyof same-day vitamin B12 supplementation in patients receiving pemetrexed for the treatment of non-small-cell lung cancer or pleural mesothelioma: aretrospective analysis.
Clin Lung Cancer.
2018;19(6):467–75.
Schlei Z, Tan W, Faber MG, Chen H, Meagher A, Dy GK.
Safetyof same-day vitamin B12 supplementation in patients receiving pemetrexed for the treatment of non-small-cell lung cancer or pleural mesothelioma: aretrospective analysis.
Clin Lung Cancer.
2018;19(6):467–75.
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