PDPN protein is expected to be a potential therapeutic target for glioma

According to a study by Zeng fan, Ph.D., Department of neuromolecular pathology, Beijing Institute of neurosurgery and Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, PDPN protein plays an important role in the occurrence and progression of gliomas, and it can be used as an important indicator of prognosis and a potential target of molecular therapy This study provides a new idea for the treatment of glioma Relevant research papers were published in the Chinese Journal of neurosurgery Podoplanin (PDPN) is a kind of transmembrane glycoprotein, which is mainly expressed in lymphatic endothelial cells It is widely used as a marker of lymphatic endothelium and lymphangiogenesis In recent years, it has been found that PDPN protein is also expressed in some malignant tumor tissues (including melanoma, lung cancer, breast cancer, etc.) At present, there are few reports about the expression of PDPN in patients with glioma and its effect on prognosis The expression characteristics of PDPN protein were analyzed in 301 patients with brain gliomas in the CGGA mRNA chip database, including 122 patients of grade II (WHO classification), 51 patients of grade III and 128 patients of grade IV Among 297 glioma patients with isocitrate dehydrogenase 1 (IDH1) status, 165 were IDH1 wild type and 132 IDH1 mutant 298 glioma patients with complete follow-up information were divided into high and low expression groups of PDPN protein, 149 in each group At the same time, the expression of PDPN in glioma patients with different databases and its relationship with clinical characteristics and prognosis were verified by gse16011, TCGA RNA sequencing and Rembrandt mRNA microarray databases The results showed that the expression of PDPN protein was the highest in grade Ⅳ glioma and IDH1 wild-type glioma, but the lowest in grade Ⅱ glioma; the expression of IDH1 wild-type PDPN protein was higher than that of the mutant, which suggested that PDPN protein could be used as a potential marker of the malignant degree of glioma The above characteristics of PDPN were verified in gse16011 mRNA chip database, TCGA RNA sequencing database and Rembrandt mRNA chip database At the same time, when analyzing the relationship between the expression of PDPN protein and the survival rate of patients in CGGA mRNA chip data, it was found that the survival period of glioma patients with high expression of PDPN protein was significantly lower than that of the group with low expression Cox single factor and multivariate regression analysis showed that PDPN protein can be used as a prognostic indicator of glioma The results of go analysis showed that the high expression of PDPN protein can lead to the decomposition and change of extracellular matrix, induce platelet aggregation and other mechanisms, thus promoting the adhesion, migration and metastasis of tumor cells, which is also related to the immune response of the body.