Pathogenesis of hypertrophic cardiomyopathy was found

Hypertrophic cardiomyopathy is one of the most common cardiovascular and cerebrovascular diseases Japan's Keio University announced in a communique Tuesday that the team had found substances that worsened the condition Hypertrophic cardiomyopathy is caused by the thickening of the heart muscle, which makes it difficult to deliver blood to the whole body Sometimes it will lead to heart failure, which is one of the causes of sudden exercise death Researchers at Keio University used somatic cells from patients with severe hypertrophic cardiomyopathy and healthy people to create iPS cells and then cardiomyocytes It is found that the myofibrils are arranged orderly in the heart cells of healthy people, but the arrangement of myofibrils in the heart cells of patients with hypertrophic cardiomyopathy is very disordered, and the contraction of the heart cells is also abnormal When the researchers further analyzed the factors that led to the deterioration, they found that a substance called endothelin-1 significantly increased the confusion of myofibril arrangement Endothelin-1 is a hormone produced when the heart bears the load due to exercise It not only exists in vascular endothelium, but also widely exists in various tissues and cells It is an important factor in regulating cardiovascular function and plays an important role in maintaining basic vascular tension At the same time, it was found that a drug called endothelin vasoconstrictor receptor antagonist could improve the disorder of myofibril arrangement and contraction of cardiomyocytes The drug has been used to treat pulmonary hypertension, and its safety to human body has been confirmed.