Oxygen transmittance test of plastic bottles for pharmaceutical packaging

Plastic bottle packaging is an important part of the pharmaceutical packaging market, with light weight, high strength, not easy to break, good sealing performance, moisture-proof, hygienic and other advantages, compared with glass containers, can be directly used for pharmaceutical packaging
without cleaning, drying.

The oxygen barrier performance of pharmaceutical plastic packaging containers is an important performance index that has an important impact on
the quality of drugs packaged inside.

The performance of plastic bottles for pharmaceutical packaging with different material structures varies greatly, and oxygen rejection is one of
them.

Plastic bottles should be reasonably selected according to the composition and storage requirements of drugs when used to package drugs, such as drugs containing ferrous salts, alcohols, ethers, aromatic amines, pyrazolone, thiophenazines and other easily oxidized components, packaging materials should be required to have high oxygen resistance, if the oxygen resistance of plastic bottles is low, that is, the oxygen permeability is high, these ingredients are easy to oxidize under the action of oxygen, resulting in drug discoloration and reduced
efficacy.

Therefore, the oxygen rejection of plastic bottles for packaging is one of
the performance indicators that should be considered when selecting pharmaceutical packaging materials.

The detection method of oxygen transmittance of packaging materials has two kinds of differential pressure method and isobaric method (Coulomb coulomb method), and the detection method of oxygen transmittance of packaging containers is GB/T 31354-2014 "Packaging and container permeability test method Coulomb meter detection method"
.

Taking a plastic bottle for pharmaceutical packaging of a brand of tablets as an example, the oxygen permeability of container plastic bottles is tested
by using the ISOBARIC-401 oxygen transmittance tester developed and produced by Jinan Saicheng.

ISOBARIC-401 Oxygen Transmittance Tester ISOBARIC-401 Oxygen Transmittance Tester Test Principle: The pre-treated specimen is clamped between the test chambers, oxygen or air flows on one side of the film, high-purity nitrogen flows on the other side of the film, oxygen molecules diffuse through the film to the other side of the high-purity nitrogen, the flowing nitrogen is carried to the sensor, and the oxygen concentration measured by the sensor is analyzed.
Calculate the results of oxygen transmittance, etc.
; For packages, high-purity nitrogen flows inside the package, and air or oxygen surrounds the outside of
the package.

ISOBARIC-401 Oxygen Transmittance Tester Introduction This product is based on Coulomb oxygen analysis sensor and isobaric test principle, designed and manufactured with reference to ASTM D3985 standard, providing high-precision and high-efficiency oxygen transmittance detection test
for high and medium gas barrier materials.

Applicable to food, medicine, medical equipment, daily chemicals, photovoltaic electronics and other fields of film, sheet, packaging and related materials oxygen permeability test
.

The instrument complies with a number of national and international standards: ASTM D3985, ASTM F1307, ASTM F1927, GB/T 19789, GB/T 31354, DIN 53380-3, JIS K7126-2-B, YBB 00082003-2015