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Overcome resistance!

 Last Update: 2022-01-11
 Source: Internet
 Author: User

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Article source: Medical Rubik's Cube Info

Author: Shi Bei

On December 15th, Nuvation announced that the US FDA has granted the company's CDK2/4/6 inhibitor NUV-422 fast track designation for the treatment of high-grade gliomas, including glioblastoma multiforme

CDK4/6 inhibitors have been shown to be effective against malignant tumors, but some cancer cells can evade cdk4/6 treatment by increasing the CDK2 signaling pathway

Pre-clinical studies have shown that NUV-422 has good blood-brain barrier penetration

Preclinical data shows that in the in vivo xenograft model of glioblastoma multiforme, NUV-422 has a better tumor suppressor effect than standard care therapy temozolomide

In addition to high-grade glioma, NUV-422 is currently being developed to treat HR+/HER2-advanced breast cancer (with or without brain metastasis) and metastatic castration-resistant prostate cancer (mCRPC)

The Phase I/II study of NUV-422 for the treatment of adult relapsed or refractory high-grade gliomas and solid tumors is ongoing

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Overcome resistance!

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