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Read: Drugs Hurt The Baby? Isn't there a placental barrier? Last year, a patient contracted a urinary tract infection during her pregnancy and decided to give her some antimicrobial medication after a consultation.
the patient read the drug instructions in great detail and thought that there might be an adverse reaction to the fetus, so he refused treatment... Such cases are not uncommon since hospitals conduct consultation clinics on pregnancy and lactation medication.
can be seen that, with the improvement of the national awareness of rational drug use, more and more mothers-to-be worry that drugs will affect the healthy development of the fetus, so the use of drugs during pregnancy to take a more cautious attitude.
is undeniable, the concerns of mothers-to-be are understandable.
women during pregnancy have a special drug use, if the drug is not used properly, it will bring serious harm to the mother and fetus.
, the types of drugs increased, the chances of drug use increased, the impact on the mother and fetus significantly increased.
on the impact on the fetus, fetal teratogenic factors are numerous, drug-caused teratogenic as one of them.
, in clinical commonly used drugs, has been identified nearly a hundred kinds of teratogenic effects.
, the possibility of malformation caused by the application of teratogenic drugs is related to the length of time, dose size and fetal age of the drug.
, the sensitivity of the fetus to the drug will vary with the age of the embryo.
Generally speaking, within 2 weeks after conception, the effect of the drug on the embryo is "all or nothing", "full" that is, early death of the embryo leads to abortion, "none" that is, the embryo continues to develop, no abnormality;
Therefore, if medication is necessary, it must be carefully and safely under the guidance of a doctor or pharmacist; in the middle and late stages of conception, the basic differentiation of the fetal organs is completed, the possibility of drug teratogenicization is greatly reduced, but some drugs may still affect the normal development of the fetus;
although there are certain risks of drug use during pregnancy, mothers-to-be must not "talk about changes in color" and over-amplify the risk that the drug may cause adverse reactions, thereby excluding all therapeutic drugs.
Many women suffer from diseases such as high blood pressure, arrhythmic disorders, viral or bacterial infections during pregnancy, as well as IVF, which require the use of drugs to keep fetuses or pregnant women safe.
because the fetus is safe only if the pregnant woman is safe.
when the advantages of medication outweigh the disadvantages, patients should receive reasonable drug treatment.
, as mentioned earlier, if the patient is not treated with medication, the infection may worsen, leading to fetal miscarriage or affect the normal development of the fetus, or even endanger the patient's own life.
For pregnant patients, it is important to be clear: if the disease needs medication, then your compliance must be good, according to the doctor's instructions to take the drug, if in the course of medication feel any discomfort, be sure to contact the doctor, may be an adverse reaction to the drug;
When choosing medication in clinical practice, in addition to informing patients of the pros and cons of the drug, it is best to follow the principle of effective use during pregnancy: single-drug effective avoidance of combination medication; Teratogenic drugs, avoid the use of drugs that may be harmful to the fetus during early pregnancy, master the gestational age, the drug is best to start after 14 weeks of pregnancy, assess the severity of the disease, if the disease must be applied to the fetus of the drug, should terminate the pregnancy before medication.
Because pregnant women in the physiological, biochemical functions and other aspects of the special effects of drugs, affecting the absorption, distribution, metabolism and excretion process of drugs, resulting in differences in pharmacodic parameters, according to conventional drug use, the drug may not reach the lowest effective concentration in the body, or higher than the minimum poisoning concentration.
therefore, individualized treatment programmes need to be developed for pregnant patients.
in addition to clinical department visits, pregnant women can also go to the pharmacist consultation clinic.
and lactating pharmacist consultation clinic of Xinhua Hospital is located in The Obstetric Clinic No. 4 and is open every Wednesday morning.
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