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Over 1.7 billion U.S. dollars to help develop ophthalmic gene therapy AbbVie reached cooperation

 Last Update: 2021-10-11
 Source: Internet
 Author: User

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On September 13, 2021, AbbVie and REGENXBIO announced a strategic cooperation agreement to jointly develop and commercialize RGX-314
.

RGX-314 is a potential one-time gene therapy for the treatment of wet age-related macular degeneration (AMD), diabetic retinopathy (DR) and other chronic retinal diseases

Wet AMD is characterized by the formation of new, leaking blood vessels in the retina, leading to loss of vision
.

RGX-314 delivers transgenes to cells via the AAV8 vector

Diabetic retinopathy (DR) is the leading cause of vision loss in adults aged 24-75 years in the world
.

As DR progresses, a large proportion of patients develop vision-threatening complications, including diabetic macular edema (DME) and neovascularization that can lead to blindness

▲Introduction of RGX-314 (picture source: REGENXBIO official website)

REGENXBIO is advancing the study of RGX-314 through two different routes of administration to the eye
.

The therapy is currently in a pivotal trial of subretinal drug delivery to treat patients with wet AMD, and two phase 2 clinical trials of drug delivery via the internal suprachoroidal space to treat wet AMD and DR patients

In addition, AbbVie will pay REGENXBIO an upfront payment of US$370 million, and REGENXBIO may receive up to US$1.

Reference materials:

[1] AbbVie and REGENXBIO Announce Eye Care Collaboration.

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