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Original analysis: inhibition of miR21, RNAi coupled with albumin in vivo

 Last Update: 2021-08-06
 Source: Internet
 Author: User

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Today, Korean scientists published an article in "ACS Nano" showing modern new drug discovery technology

Drug source analysis

Recently, mRNA vaccines, ASO, and RNAi have been launched to speed up the entire RNA technology sector.

However, controlling the expression of multiple proteins does not mean that drugs cannot be made.

Today’s work uses a highly selective RNAi to inhibit a wide-ranging oncogenic RNA (miR21), so it is somewhat similar to epigenetic protein inhibitors such as EZH2

The MSA-Anti-21 produced by the reaction of MI-anti-21 with albumin in vivo is almost the same as the complex PK synthesized in vitro, indicating that the in vivo reaction is very efficient and free RNAi is immediately captured by albumin after entering the blood

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