Oral Dis: Oral cancer-related fibroblasts are a risk factor for poor prognosis.

This systematic review and meta-analysis is designed to analyze the correlation between cancer-related fibroblasts (CAFs) and death risk in patients with oral squamous cell carcinoma.
analysis of the English literature (1966-2018), these studies assessed CF density through alpha-smooth actoprotein immunology, and presented a five-year survival rate through Kaplan-Meier.
also collected the average age of patients in each study, the proportion of male/female patients, and the male/female majority (male/female patients.
level of the statistical model is p 0.05.
results, meta-analysis included 11 studies/1,040 patients.
single-variable Cox regression shows that high CF density was a negative prognosmulative factor in female and male-dominated studies .OR 5.329 (95% CI 3.223-8.8, respectively) 11), p .lt;0.001, and OR 2.208 (95% CI 1.717-2.839), p .lt;0.001.
male-dominated studies, high CF density was associated with a more favorable prognosmical effect .OR 0.996 (95% CI 0.979-1.013), p .lt;001.
multivariable Cox regression showed that the risk of death in patients with high CAF density was significantly higher than in patients with low CAFs (OR 2.741 (95% CI 2.220-3.384) p slt; 0.001.
high average age and male ratio have significant protective effects .OR 0.940 (95% CI 0.925-9.955), p .lt; 0.001, OR 0.125 (95% CI 0.018-0.867), p . . . 0.035).
, the results show that CAFs increase the risk of death, with men in the majority and a higher average age as protective.
clinically proven CF density threshold can be used as a reliable prognosmation tool.
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