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Researchers from Queen's University Belfast have revealed how a defined protein pathway leads to early diagnosis and targeted therapy of several cancers and brain diseases
During brain development, neural stem cells give rise to neurons, which then migrate to specific locations in the brain where they form connections and mature functionally
Cancer is the leading cause of death worldwide, killing nearly 10 million people in 2020, accounting for nearly one in six deaths
Epithelial-to-Mesenchymal Transition (EMT) is a specialized molecular pathway that enables cell migration and is critical for early developmental processes, including brain development and wound healing in later life.
This research not only sheds light on the development of one of the most important organs in our body, the brain, but also shows that the same protein that is essential for brain development may also be the cause or target of cancer spread in the body, the real Jekyll and Hyde protein
During brain development, new neurons migrate into place in the same way that tumor cells acquire migratory potential, which leads to the movement of cancer throughout the body, or cancer metastasis
"By identifying key regulators of these pathways, we open up new opportunities for therapeutic intervention in cancer and better understand neurodevelopmental disorders involving deficits in brain development," the authors conclude