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Oncologist: Efficacy and safety of Pembrolizumab (pembrolizumab) combined with CAPOX (oxaliplatin + capecitabine) in advanced cholangiocarcinoma (BTC)

 Last Update: 2022-04-23
 Source: Internet
 Author: User

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Recently, the journal Oncologist published the results of a phase II clinical study evaluating the use of the PD-1 inhibitor pembrolizumab (pembrolizumab) in combination with CAPOX (oxaliplatin + capecitabine) in advanced cholangiocarcinoma (BTC).
Efficacy and safety of treatment
.

The patients studied were histologically confirmed BTC, pembrolizumab + oxaliplatin d1, capecitabine bid d1-d14 for 6 cycles

The study included 11 patients, with a median age of 67 years (51-81 years), and 55% of patients were women

PD patients received an average of 5.

The median progression-free survival was 4.

1 months (95% CI: 2.

The median progression-free survival was 4.

The most common grade 3 and 4 adverse events were decreased lymphocyte count (64%), anemia (36%), decreased platelet count (27%), and hyponatremia (27%)

In conclusion, the study shows that capecitabine + oxaliplatin combined with pembrolizumab is tolerable and is a potentially effective treatment for refractory advanced BTC

Original source:

Cecilia Monge, Erica C.

Pehrsson, Changqing Xie, et al.

Cecilia Monge, Erica C.
Pehrsson, Changqing Xie, et al.
A Phase II Study of Pembrolizumab in Combination with Capecitabine and Oxaliplatin with Molecular Profiling in Patients with Advanced Biliary Tract Carcinoma.
The Oncologist, 2022, 27, e273–e285.
https: https://doi.
org/10.
1093/oncolo/oyab073 .
https://doi.
org/10.
1093/oncolo/oyab073 https://doi.
org/10.
1093/oncolo/oyab073 .
.
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