Oncogenesis: Rae Gongto extract helps treat pancreatic cancer

December 18, 2020 /--- City of Hope affiliate Translational Genomics Research Institute (TGen) researchers conducted a preclinical study results show that Lei Gongto, a Chinese herbal medicine used in China for hundreds of years to treat joint pain, can effectively kill cancer cells and may improve clinical outcomes in patients with pancreatic cancer.
Regongto meth is the main active ingredient of Regongto and is the basis of the water-soluble drug preaganic Minnelide, which appears to attack the pancreatic cancer cells and the substations around the tumor, thereby strengthening the effects of the body's immune system on it.
researchers recently published their findings in the journal Oncogenesis.
study found that the compound's role is to destroy the so-called pancreatic cancer surrounding the substitli, that is, to maintain the genetic stability of pancreatic cancer cells need a series of DNA and cancer-related fibroblasts.
Hairong Han, a professor in the TGen Department of Molecular Medicine and one of the study's senior authors, said: "The growth and survival of cancer cells depends on super enhancers.
(Image source: www.pixabay.com) "We found that by destroying the outer periline substring, Regongto meth could attack not only cancer cells, but also the substrings, which helps accelerate cancer cell death."
Han han said: "Although Regongto meth is a versatile transcription inhibitor and an effective anti-tumor agent, we are the first to report its role in regulating gene expression, especially cancer-causing gene expression, in regulating super-enhancers."
" he is also the head of the basic research department of the TGen Pancreatic Cancer Program.
pancreatic cancer is the third leading cause of cancer-related deaths in the United States, killing more than 47,000 Americans each year.
Daniel Von Hoff, another senior author of the study and a distinguished professor at TGen, said: "There is an urgent need to develop therapeutic strategies that not only target tumor cells, but also regulate substring cells.
based on our findings, reprogramming super-enhancers with regulatory compounds such as retocin may provide an effective treatment option for pancreatic cancer patients.
" (Bioon.com) Source: Compound derived from from thunder god vine can help pancreatic cancer patients Original source: Pawan Noel et al, Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts, Oncogenesis (2020). DOI: 10.1038/s41389-020-00285-9。