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Dementia rates are on the rise around the world, with some studies reporting higher rates in women than in men, but there is limited evidence on reproductive factors and dementia risk
.
Using data from the UK Biobank, Jessica Gong and colleagues at the George Institute for Global Health in Australia looked at all dementia risk and reproductive factors in 273,240 women and 228,965 men, as well as the number of children these women had
After controlling for age, socioeconomic status, smoking, body mass index (BMI), and other elements, certain events were associated with shorter cumulative exposure to internal estrogen production, such as older than average age in the first stage, and lower than average age at menopause Being younger and having a hysterectomy is associated with a higher risk of dementia
.
Pregnancy, even miscarriage, longer childbearing years, older menopause, and use of birth control pills were all associated with a lower risk of all-cause dementia
The study has limitations, including a retrospective report on reproductive factors that could be biased, and the fact that the UK Biobank is a relatively healthy affluent population of white British ancestry and therefore may not be representative of the wider population
.
Gong added: "Reproductive activity with shorter exposure to endogenous estrogens in women is associated with a higher risk of dementia, and these findings underscore the vulnerability of women to dementia risk
.
However, this was observed in both women and men.
Journal Reference :
Jessica Gong, Katie Harris, Sanne AE Peters, Mark Woodward.
