Obesity-related genetic mutations may help reduce the risk of diabetes

why are some obese people less likely to develop diabetes? Some of the genetic variants associated with obesity may help reduce the risk of type 2 diabetes, heart disease and stroke, according to a new study published by the University of Exeter.
previous studies have suggested that excess body fat stored around the waist or liver may be genetically determined. To test this theory, researchers at the University of Exeter, Brunel University and others worked together to analyse data from more than half a million people in the UK's biological sample bank, aged between 37 and 73. The researchers analyzed MRI scans of the men's waists and analyzed the relationship between their excess fat storage and their risk of type 2 diabetes, heart disease and stroke.
body mass index (BMI) is a common measure of weight and thinness, calculated by divided by weight (kg) by the square of height (meters). Normal values are generally considered to be between 20 and 25, more than 25 are overweight, and more than 30 are obese.
found that 14 genetic variants of DNA (deoxyric acid) molecules were associated with higher levels of body mass index, but also with lower risk of diabetes, blood pressure and heart disease.
researchers believe this may be because this genetic mutation regulates where excess body fat is stored - people who carry these genetic factors, most of which are stored under the skin, and those who store less fat around major organs such as the liver, pancreas and kidneys, reduce the risk of related diseases.
, one of the study's authors and a professor at Brunel University, said that in the cases of diabetes and other diseases, where excess body fat is stored is more important than how much fat the body itself has. " (Fat) is better stored directly under the skin than around organs, especially the liver."
study has been published in the American Journal of Diabetes. (Source: Zhang Jiawei, Xinhua News Agency)