Obesity leads to diabetes protein trouble
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Last Update: 2015-07-24
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Source: Internet
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Author: User
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Japanese researchers have found that a protein produced by fat cells after obesity can be a trigger for diabetes, and inhibiting the function of this protein can alleviate the symptoms of diabetes This finding will contribute to the prevention and treatment of diabetes Professor shijingyou and others from Osaka University in Japan reported in the new online edition of the Journal of the National Academy of Sciences that obesity can cause chronic inflammation of fat cells, which is believed to be related to diabetes But researchers have been unclear about what causes inflammation in fat cells The researchers fed the mice high-fat and high calorie foods After 8 weeks, the mice weighed twice as much as usual and developed diabetes It was found that in the first week when the body weight of the experimental mice had not changed, a protein called S100A8 in the adipocytes began to increase, activated macrophages in the immune cells, and induced inflammation of the adipocytes Since then, the researchers injected the substance that can inhibit the function of the protein into the diseased mice twice a week As a result, the diabetes symptoms of the mice were successfully relieved, and the effect of insulin injection was also improved Because the protein is also present in the human body, the team plans to develop drugs to prevent and treat diabetes based on it, so as to reach the practical level in 5 to 10 years.
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