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without permission.
Introduction: Studies have confirmed that obesity is associated with a poor prognosis for a variety of cancers, and a study by Chinese scholars found that papillary thyroid carcinoma (PTC) is also potentially affected by obesity, which was presented at the 2022 American Thyroid Association Annual Meeting (2022ATA).
Explore: Potential effects of obesity on PTC aggressiveness
Currently, the potential effect
of body mass index (BMI) on the aggressiveness of papillary thyroid carcinoma (PTC) is unclear.
A retrospective analysis study was conducted
on 1720 patients with PTC who underwent total thyroidectomy or lobectomy from January 2017 to April 2020.
According to the patient's BMI, they were divided into 2 groups: the control group (CON, BMI<24kg/m2) and the overweight/obese group (OB, BMI≥24kg/m2), and each group was analyzed
separately.
PTC aggressiveness in men is associated with body mass index
➤ In the whole cohort, the OB group had higher rates of extrathyroidial dilation (21.
5% vs.
16.
8%, P=0.
013), multifocal (43.
2% vs.
37.
7%, P=0.
018), and BRAF-V600E (82.
9% vs.
79.
3%, P=0.
015)
compared to the CON group.
In men, tumors in the OB group were more than 1 cm in size (54.
4% vs.
42.
7%, p=0.
008), extrathyroidal extension (24.
9% vs.
12.
4%, P=0.
001), and multifocal (42.
7% vs.
33.
5%, P=0.
038)
compared with CON.
➤ In addition, in the obese group, extrathyroid elongation (30/100, 30.
0%, P=0.
001) and tumor size over 1 cm (65/100, 65.
0%, P=0.
001), significantly higher than the overweight and CON groups
.
➤ Compared with CON, the obese group showed tumor size of more than 1 cm, thyroid extensibility and multifoci.
Summary of this article
These studies have shown that overweight and obesity are the main independent risk factors for aggressive PTC in men, and these data suggest that clinical treatment decisions should be based on risk stratification
of male BMI.
REFERENCE: LONG‐TERM MORTALITY AND CARDIOMETABOLIC EFFECTS OF TREATMENT FOR HYPERTHYROIDISM: EGRET STUDY.
THYROIDVolume 32， Supplement 1，2022.
https：//doi.
org/10.
1089/thy.
2022.
29140.
lb.
abstracts
