NPJ Regenerative Medicine: Xiang Wenpei's team at Huazhong University of Science and Technology established a new method of ovarian tissue transplantation to provide new strategies for protecting women's fertility

Recently, Professor Xiang Wenpei's team from the Institute of Reproductive Health of Tongji Medical College of Huazhong University of Science and Technology published a report titled "Multi-biofunctional graphene oxide-enhanced poly-L-lacticacid composite nanofiber scaffolds for ovarian function" in the journal npj Regenerative Medicine A research paper
on recovery of transplanted-tissue.

Aiming at the difficult points in the field of female fertility protection - the key problems of large number of follicles lost and tissue survival after ovarian tissue transplantation, this research has innovatively combined with materials engineering to establish a new method
of ovarian tissue transplantation.

The research team first innovatively constructed a polylactic acid/graphene oxide (PLLA/GO) composite nanofiber scaffold, and the special structure of its hydrophilic surface and porous network is highly favorable for cell infiltration and post-implantation infiltration, suitable for a wide range of tissue engineering applications; The optimal conditions for graphene oxide concentration in PLLA/GO composite nanofiber scaffolds for cultured granular cells were further determined, providing a basis for the use of materials for joint transplantation of ovarian tissue; Then, the effect of 1.

Professor Xiang Wenpei of the Institute of Reproductive Health of Tongji Medical College of Huazhong University of Science and Technology, Academician Zhao Yuliang of the National Center for Nanoscience, Professor Xiao Xianjin of the Institute of Reproductive Health of Tongji Medical College of Huazhong University of Science and Technology, and Chief Physician of the Daniel Zhang of Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology are co-corresponding authors
。 Professor Xiang Wenpei has been engaged in the research and teaching of reproductive medicine for a long time, dedicated to ovarian aging and stem cell transformation research, and has published more than 50 papers as the first author/corresponding author, and the relevant results have been published in Science Advances, Journal of Advanced Research, Aging-US, Antioxid Redox Signal, Human Reproduction and other journals
。 The series of original achievements of Professor Xiang Wenpei's team have played a positive role
in promoting the reproductive health of women of childbearing age.

Original Source:

Yan， L.