npj Parkinsons Dis: Zhejiang University - The age of onset of Parkinson's disease is different, and the immune status is different

Parkinson's disease (PD) is the second most common neurodegenerative disease; it is characterized by progressive death of dopaminergic neurons and accumulation of Lewy bodies, particularly alpha-synuclein
.

Recent evidence suggests that neuroinflammation plays an important role in Parkinson's disease

Parkinson's disease (PD) is the second most common neurodegenerative disease; it is characterized by progressive death of dopaminergic neurons and accumulation of Lewy bodies, particularly alpha-synuclein

In particular, previous studies have linked PD to autoimmune disease, microglial activation, histopathology of peripheral immune cell infiltration in the brain, and immune cell and cytokine dysregulation in peripheral blood
.

An abnormal immune system increases susceptibility to PD;

In particular, previous studies have linked PD to autoimmune disease, microglial activation, histopathology of peripheral immune cell infiltration in the brain, and immune cell and cytokine dysregulation in peripheral blood

Therefore, identifying pathogenic immune targets is crucial to provide a new direction for exploring the pathogenesis of PD

Notably, α-syapsin-reactive T cells could be detected even 10 years before PD diagnosis ; this supports a role for immune inflammation in PD pathogenesis

In particular, one study found high levels of interleukin-4 (IL-4), IL-6, and IL-10 expression in PD patients; of these, IL-6 was associated with an increased risk of death

In this way, Jun Tian et al.
from the Second Affiliated Hospital of Zhejiang University explored the specific immune cell subtypes in the peripheral blood of PD patients of different onset ages

They included 22 patients; 10 with early-onset PD (EOPD), 12 with late-onset PD (LOPD), 10 young healthy controls (YHCs) and 8 elderly HCs (EHCs)

Accurate immunophenotyping of cell populations in peripheral blood was performed using mass spectrometry staining

T-test and ANOVA statistical analysis were performed on the frequencies of annotated cell populations
.

Linear regression models were used to analyze the correlation between cell populations and clinical symptoms

T-test and ANOVA statistical analysis were performed on the frequencies of annotated cell populations

They characterized 60 cell populations and found that the immune signature of PD consists of changes in cell populations, including a decrease in effector CD8+ T cells, a decrease in cytotoxic natural killer (NK) cells, and an increase in activated monocytes in PD patients

CD8+ T cells, NK cells, and monocytes are all associated with PD
.

In addition, there may be some differences in the immune status of EOPD and LOPD patients, suggesting that the pathogenesis of these two groups of patients is different
.

In addition, there may be some differences in the immune status of EOPD and LOPD patients, suggesting that the pathogenesis of these two groups of patients is different
.

Original source:

Original source:

Tian J, Dai SB, Jiang SS, et al.
Specific immune status in Parkinson's disease at different ages of onset.
npj Parkinsons Dis.
2022;8(1):5.
doi:10.
1038/s41531-021-00271-x

Tian J, Dai SB, Jiang SS, et al.
Specific immune status in Parkinson's disease at different ages of onset.
npj Parkinsons Dis.
2022;8(1):5.
doi:10.
1038/s41531-021-00271-x here message