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Perivascular spaces (PVSs) are fluid-filled spaces surrounding blood vessels that pass through the brain parenchyma from the brain surface
Perivascular spaces (PVSs) are fluid-filled spaces surrounding blood vessels that pass through the brain parenchyma from the brain surface
Figure 1 Title map of the paperFigure 1 Title map of the paper
Although findings on PVS remain controversial, PVS burden has been shown to be associated with aging, cognitive performance, sleep quality, and depressive status
Although findings on PVS remain controversial, PVS burden has been shown to be associated with aging, cognitive performance, sleep quality, and depressive status
PD is a chronic neurodegenerative disease characterized by motor symptoms (resting tremor, bradykinesia, stiffness, and abnormal gait) and non-motor symptoms (depression, anxiety, cognitive decline, etc.
Recent studies have shown that the PVS system plays a disease-modifying role in Parkinson's disease
Therefore, the small size of PVS should also be considered in studies of neurodegenerative diseases, which may alter the correlation between PVS burden and clinical features compared to previous studies
In this way, Ting Shen1 et al from Zhejiang University compared the PVS burden of early PD with that of healthy controls (HCs), including the effect of smaller PVS
They quantitatively assessed PVS burden on 7T MRI images to explore the prevalence of PVS and described the correlation pattern of PVS burden with clinical and imaging features to further understand its pathophysiological mechanism in PD
They recruited 40 early-stage PD patients and 41 healthy controls (HCs)
They also compared PVS burden between PD and HC and performed partial correlation analysis between PVS burden and clinical and imaging characteristics
Figure 2 Schematic diagram of PVS
Figure 2 Schematic diagram of PVSAnisotropy and mean diffusion rate values of certain subcortical nuclei and white matter fibers in or near the BG and midbrain were significantly associated with ipsilateral PVS burden indicators
Anisotropy and mean diffusion rate values of certain subcortical nuclei and white matter fibers in or near the BG and midbrain were significantly associated with ipsilateral PVS burden indicators
In the midbrain, differences in bilateral PVS burden were associated with differences in the number of fibers passing through the white fiber tracts of the bilateral substantia nigra, respectively
Our study demonstrates that the PVS burden index is a candidate biomarker for assessing the severity of motor symptoms in PD and helps predict drug dosage
.
The findings also highlight a potential association between PVS burden and gray and white matter microarchitecture
.
The PVS Burden Index is a candidate biomarker to assess the severity of motor symptoms in PD
Original source:
Shen T, Yue Y, Zhao S, et al.
The role of brain perivascular space burden in early-stage Parkinson's disease.
npj Parkinsons Dis.
2021;7(1):12.
doi:10.
1038/s41531-021- 00155-0
Original source:
Shen T, Yue Y, Zhao S, et al.
The role of brain perivascular space burden in early-stage Parkinson's disease.
npj Parkinsons Dis.
2021;7(1):12.
doi:10.
1038/s41531-021- 00155-0 The role of brain perivascular space burden in early-stage Parkinson's disease.
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