npj Parkinsons Dis: In REM sleepers, blood metabolites predict future disease risk

Neurodegeneration associated with Lewy bodies and aggregated alpha-synapsin (Lewy-type synaptopathies; LTS) clinically manifests as Parkinson's disease, usually associated with advanced-onset dementia (ie, Parkinson's disease (PD) ), although dementia can also appear as an early feature and was then named dementia with Lewy bodies (DLB)

Neurodegeneration associated with Lewy bodies and aggregated alpha-synapsin (Lewy-type synaptopathies; LTS) clinically manifests as Parkinson's disease, usually associated with advanced-onset dementia (ie, Parkinson's disease (PD) ), although dementia can also appear as an early feature and was then named dementia with Lewy bodies (DLB)

Figure 1 Title map of the paper

Figure 1 Title map of the paper

Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a parasomnia characterized by intense dream behavior and REM sleep muscle atony

Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a parasomnia characterized by intense dream behavior and REM sleep muscle atony

Although iRBD patients have no apparent neurological disease, long-term prospective studies have shown that more than 90% of patients develop LTS within 14 years of iRBD diagnosis, and the remaining disease-free patients show short-term risk markers for developing LTS

Therefore, iRBD is a clinical marker of the prodromal phase of LTS, providing a good opportunity to study the early stages of LTS

iRBD and LTS are associated with cardiovascular risk factors and inflammatory processes

However, this type of approach has not been explored before in the context of iRBD

Hereby, Ariadna Laguna et al.

They used nuclear magnetic resonance (NMR) spectroscopy to assess the lipoprotein and protein glycosylation profiles of 82 iRBD patients collected before and/or after their switch to overt LTS, as well as 29 matched controls Serum samples

Data were statistically analyzed to identify altered metabolites and build predictive models

However, clear differences were found when the analysis differentiated patients with iRBD initially presenting with Parkinson's disease (pre-PD) or dementia (pre-DLB)

Figure 2 Schematic diagram of metabolic changes

Fig.

Significant differences were also found when analyzing paired iRBD samples before and after LTS diagnosis

They built predictive models and differentiated between controls and pre-DLB patients, and pre-DLB and pre-PD patients

This provides evidence of altered lipoprotein and glycosylation profiles in a subgroup of iRBD patients

These results suggest that metabolic alterations and inflammation are involved in the pathophysiology of iRBD and suggest biological differences in LTS progression in iRBD patients
.
Analysis of serum samples by MRI may be a useful tool to determine whether short-term high-risk iRBD patients will convert to Parkinson's disease or dementia
.
Metabolic alterations and inflammation are involved in iRBD pathophysiology and suggest biological differences in LTS progression in iRBD patients

 

Original source:
Laguna A, Xicoy H, Tolosa E, et al.
Serum metabolic biomarkers for synucleinopathy conversion in isolated REM sleep behavior disorder.
npj Parkinsons Dis.
2021;7(1):40.
doi:10.
1038/s41531-021-00184 -9

Original source:
Laguna A, Xicoy H, Tolosa E, et al.
Serum metabolic biomarkers for synucleinopathy conversion in isolated REM sleep behavior disorder.
npj Parkinsons Dis.
2021;7(1):40.
doi:10.
1038/s41531-021-00184 -9 Serum metabolic biomarkers for synucleinopathy conversion in isolated REM sleep behavior disorder.
npj Parkinsons Dis.


Leave a comment here