Npj breath cancer: a new compound or potential to block the activity of the main regulator promoting cancer growth and metastasis

January 16, 2020 / BIOON / -- recently, an international magazine npj bread cancer In the previous research report, scientists from the University of Illinois at Urbana Champaign have developed a new drug compound, which can effectively block the cancer promoting activity of FoxM1, a special transcription factor that can regulate the activity of multiple genes This new type of compound can effectively inhibit human cells and tumors in various types of mouse models of human breast cancer The growth of Photo source: L Brian Stauffer FoxM1 is a naturally produced protein, which can increase the expression of genes that are very important for cell proliferation and development This gene plays a very important role in the early development process, but under normal circumstances, its expression level in adult tissues is relatively low In this paper, researchers focus on the research of FoxM1 gene, compared with that in healthy human cells, FoxM1 gene FoxM1 is a key factor that makes breast cancer and many other cancers more aggressive and difficult to treat Because it is the main regulator of cancer growth and metastasis, researchers are very interested in developing new compounds to effectively block its function At present, there is no successful drug preparation that can effectively block the effect of FoxM1 In addition, there are other reported inhibitors of FoxM1, but their effect is usually low, and they can not play a good role in vivo In this study, the new compounds developed by the researchers have better antitumor effect It has good activity in vivo and good half-life in blood Some oral drugs have good effect, which is exactly what patients need finally In this paper, the researchers developed new drugs by analyzing the characteristics of a variety of compounds in the chemical library of potential therapeutic agents They screened new compounds that can reduce the proliferation of breast cancer cells and inhibit the expression of genes regulated by FoxM1 Later, the researchers modified these compounds to enhance the inhibition of FoxM1 and increase the inhibition Cell potential, three of the compounds tested performed well Benita katzenellenbogen, the researcher, said that these compounds can effectively inhibit the growth of breast cancer cells representing the main subtypes of breast cancer, including estrogen receptor positive, HER2 positive and triple negative breast cancer, and they can also block human breast cancer in mouse models The research results are very meaningful, but it is still in the early stage, later researchers may need to conduct in-depth research to develop new anticancer drugs Researchers usually use combination drugs to treat cancer, and later researchers need to further study to explain how FoxM1 inhibitors can be combined with other standard treatment agents to improve cancer treatment Original sources: Ziegler, Y., laws, M.J., Sanabria Guillen, V et al Supply of FoxM1 activities and breast cancer growth in vitro and in vivo by a new class of complexes Npj breast cancer 5, 45 (2019) doi: 10.1038/s41523-019-0141-7