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Novo Nordisk's GLP-1+GIP combination treatment of type 2 diabetes new drug clinical application approved

 Last Update: 2021-11-04
 Source: Internet
 Author: User

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Article source: Medical Rubik's Cube Info

Author: Sunshine

Recently, CDE official website showed that Novo Nordisk NNC0480-0389 injection combined with smeglutide injection to assist diet and exercise to improve the blood sugar control of patients with type 2 diabetes has been approved for clinical application of a new drug
.

NNC0480-0389 injection is an analog of GIP (glucose-dependent insulinotropic polypeptide)
.

The structure and function of GIP are similar to GLP-1 (glucagon-like peptide-1).

Smeglutide was approved by the State Administration on April 29 this year to assist diet and exercise to improve blood sugar control in patients with type 2 diabetes
.

It is an analog of human glucagon-like peptide-1 (GLP-1), which activates GLP-1 receptor by simulating natural GLP-1, enhances insulin secretion and inhibits glucagon in a glucose concentration-dependent manner Secretion can delay gastric emptying and reduce food intake through central appetite suppression, thereby reducing blood sugar

Compared with GLP-1 receptor agonist monotherapy, the synergistic weight loss effect of GIP and GLP-1 receptor agonists is more superior, and it can improve the metabolism of blood lipids and blood sugar

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