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    Home > Active Ingredient News > Antitumor Therapy > Note! Children's chemotherapy drugs are careful of "ototoxicity"

    Note! Children's chemotherapy drugs are careful of "ototoxicity"

    • Last Update: 2022-09-14
    • Source: Internet
    • Author: User
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    As one of the most commonly used drugs in current combination chemotherapy, cisplatin is effective against a variety of solid tumors, but its incidence of nephrotoxicity is high, so it requires a lot of hydration



    At the same time, it is important to pay attention to the therapeutic dose, so how should cisplatin be applied in pediatric patients? What do I need to be aware of? Let's learn together!



    How to treat a variety of solid tumors?

    When cisplatin is used to treat a variety of solid tumors, the recommended dosages are as follows:


    1.



    2.



    In addition, depending on the child's body weight, cisplatin should be diluted with an appropriate amount of sodium chloride injection




    FDA: Be careful with ototoxicity

    Ototoxicity may be more severe in children receiving cisplatin injection, especially those younger than 5 years of age, with an estimated prevalence of hearing loss in children ranging from 40% to 60%.



    The FDA recommends hearing and vestibular function tests for all pediatric patients receiving cisplatin because early detection of hearing impairment can limit its potential impact on


    More Corey's Top Drugs, Where to Learn? Pediatric medication is no small matter, some drugs do not have the corresponding dosage form for children, can children use it? Should the dose be adjusted for application?
    Polyene phospholipidamide contains benzyl alcohol, which is contraindicated in children! The Food and Drug Administration warns infants and young children under 2 years of age to use aminophenanthrine with caution.
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    What other drugs are contraindicated in children?
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