Nopp Regeneration: Self-researched bio3D printing platform to meet the huge demand in tissue and organ repair field with clinical orientation

Guide: With its fastness, accuracy and ability to produce complex solids, bio3D printing has become the most popular technology in the field of regenerative medicine, attracting many enterprises, Nopu Regeneration is one of thebio3D printing technology is designed to 3D imaging of artificial tissues and biological organs, and then use computer-aided design of 3D models, and model slayerand and numerical programming, to process active materials including biological materials, growth factors, cells and other componentswith its fastness, accuracy and ability to make complex entities, bio3D printing has become the most popular technology in the field of regenerative medicine, attracting a number of enterprises, Nopp Regeneration is one of themNop Regeneration was founded in 2016 as a high-tech company specializing in bio-3D printing, focusing on the development of clinically accessible products using bio-3D printing technology for tissue and organ repair, the company has developed an OPUS (OrganPrinting United System) printing platform suitable for clinical applications, can print active soft tissue products, hard tissue implants, etc., can be compatible with a variety of biological cells, creating a suitable for long-term cell survival of the microenvironmentRegenerative medicine has ushered in the technology alternating nodes, bio3D printing potential is revealed
bio3D printing technology made of regenerative tissue engineering products application prospects are very broad, Nop regeneration is aimed at the field of tissue and organ repairdue to aging, accidents, trauma, chronic diseases and other reasons, China has a large number of tissue repair and organ transplantation needs every yeardata show that china's annual bone defects and bone injury patients about 3 million people, skin defects about 4 million patients, 1.5 million patients waiting for organ transplants each year-self-transplantation and allogeneic transplantation are commonly used in the field of tissue and organ repairHowever, the self-transplantation has great restrictions on the donor region, the rejection reaction of allogeneic transplantation, and the contradiction between supply and demand of Chinese donors is great, and the satisfaction rate of transplanted organs is only 1:150in this case, regenerative tissue engineering products have become a breakthrough to solve the contradiction between supply and demand in the field of tissue and organ repair"
tissue and organ restoration has reached a critical point of technological replacement, and bio-3D printing technology has great potential in this field, " said Yang Xi, co-founder and CEO of Knopu Regenerationbased on this judgment, the company's founding team founded Knopp Regeneration in 2016everyone is a specialist in the field of sub-sectors, but also a generalist in the cross-cutting fieldbio3D printing technology is a cross-discipline, involving regenerative medicine, materials science, mechanical engineering, digital medicine and so on At present, Noep Regeneration has set up a group of experienced, diversified team, both in the skin regeneration field has more than 20 years of experience in the field of regenerative medicine experts, but also in the field of materials science, machinery manufacturing, medical equipment precipitation for decades of professionals, as well as in the transformation of innovative products have more than 10 years of experience in the industry "The professional background of The Core Team of Nopp Regeneration solves some of the core technical problems of bio-3D printing today, while transforming cutting-edge technology into products." at the same time, Yang Xi stressed: "
" company everyone is not only a division of expertise, but also a cross-section of the generalists "
Nop Regeneration has always been developed in a clinical-oriented manner In the product project and research and development process, the research and development staff will learn medical knowledge, go to the hospital to observe the operation, so that the product better serve the doctor and patients clinical requirements-oriented, the introduction of clinical-friendly bio3D printing system
at present, Noep Regeneration has independently developed a full solution for bio3D printing based on OPUS multi-process integrated printing platform, including OPUS printing platform, efficient biological ink development system, and clinically practical printing process According to Yang Xi, the core competitive core of the OPUS platform is embodied in two aspects: enables simultaneous printing of bioprinting materials (cells, natural macromolecules, synthetic polymers, etc.) products that need to be printed are both soft and hard, and have heterogeneity Simply put, different materials require different printing processes and printers The OPUS platform enables simultaneous partition printing of high and low viscosity, high and low temperatures, and materials in a variety of cross-linked curing methods OPUS platform breaks through the limits of ordinary print size and meets the environmental control requirements of clinical product development traditional bio-3D printer can only print a small size of products, can not meet the needs of clinical printing bones and other large-size products, and OPUS in the printing size, can adapt to the human size of a molded printing A wide range of bio-inks developed for cell printing, which print skin, cartilage, interstitial stem cells, create a microenvironment suitable for long-term cell survival, and is easy to print, supporting a wide range of clinical applications The key to printing process is to construct a fine three-dimensional structure, simulate a microenvironment similar to the extracellular interstitial, promote the functionalization of tissues or organs after transplantation, vascularization, etc., while Noop attaches great importance to clinical practicality, taking into account mechanical strength, biocompatibility, surgical procedure and ease of use OPUS printing platform is a truly practical solution for multiple scenarios
based on the OPUS printing platform, Nopp Regeneration is developing a range of hard and soft tissue repair products "The company is in small batch production and is actively promoting clinical trials," Mr Yang said It is expected to be able to obtain a registration certificate within three years at the same time, in the development process, Nopp regenerative bio3D printing platform OPUS has been highly recognized by a number of hospitals and research institutions 2019, Noep Regeneron officially launched the OPEN-LAB program, launching 3D bioprinting services on the OPUS platform, providing new bio-3D printing-based solutions to leading medical institutions and industrial customers it is understood that, up to now, Nopp Regeneration and dozens of medical institutions and other institutions reached a cross-medical, scientific research services, such as cooperation, more than 100 service projects Bio3D printing is the most cutting-edge area of 3D printing research
data show that the global 3D printing industry in 2018 total output value of 9.68 billion U.S dollars, 2024 global total output value will reach 35.6 billion U.S dollars Among them, medical 3D printing accounted for 28% to 37% of the total industry In 2018, the global medical 3D printing market reached $3.42 billion, and the medical 3D printing market is expected to reach $9.639 billion by 2024 as the most cutting-edge field of medical 3D printing research, the bio3D printing market will also grow rapidly, is expected to become the field of large-scale promotion of 3D printing technology Yang Xi clearly felt that compared with previous years, the field of biological 3D printing has never been more active, related scientific research is more and more, new enterprises are also emerging "In short, compared to previous years, the industry has made great progress and breakthroughs, the future Ofp Regeneration and industry partners to work together to promote the development of the industry." but Yang Xi also mentioned that China's bio-3D printing market industry base is still very weak, the industrial chain is not perfect Many of the raw materials used in bio-3D printing are also imported In addition, in terms of talent pool, China also lacks experience in bio-3D printing research and development ", "these objective factors determine that the overall path of bio-3D printing products is very long, high barriers to entry But once entered, the product life cycle will be very long, high barriers and high efficiency coexist Nop Regeneration is actively working with the industry chain upstream and downstream, actively training medical cross-team, hoping to quickly promote the product to market, in the field of bio-3D printing to occupy a place "