Newly discovered fibromuscular dysplasia gene

A new study shows that three new gene variants that regulate arterial gene expression are related to fibromuscular dysplasia
.
Fibromuscular dysplasia is a disease of the arteries that can have dangerous consequences for the heart and blood vessels

The research results published in Nature Communications by an international team of foot-and-mouth disease experts from the United States and Europe also confirmed the importance of the fourth genetic target that has been confirmed to be related to foot-and-mouth disease
.

"We used to think that hand-foot-mouth disease is a rare disease, but the current estimate is that it may affect more than 3% of the population," said the article's second and co-corresponding author Sandra Jean Ganesh, MD, Internal Medicine Associate Professor of Medicine and Human Genetics and Cardiologist at the University of Michigan Health Frankel Cardiovascular Center
.
"We continue this research in order to better understand the cause of foot-and-mouth disease, which is crucial

The researchers pointed out that the identified genes indicate that the genetic basis of FMD may be through changes in the structure and function of vascular smooth muscle cells

It is worth noting that these genetic findings point to a correlation with several more common cardiovascular diseases, including hypertension, migraine, intracranial aneurysm, and subarachnoid hemorrhage
.
This is negatively related to atherosclerotic coronary artery disease, and ischemic stroke (which also often affects patients with foot-and-mouth disease) has no common inheritance

"These findings provide new biological insights for further study of this interesting situation, genes and pathways to determine the therapeutic target of foot-and-mouth disease," said co-senior and co-corresponding author Dr.
Nabila Bouatia-Naji, a French national researcher The research director of Santé et la Recherche Médicale, also known as INSERM, is the team leader of the Paris Cardiovascular Research Center
.

Ganesh and Bouatia-Naji’s team combed through the genome-wide association study data of more than 1,500 foot-and-mouth disease cases and compared them with more than 7,000 control samples from non-foot-and-mouth disease participants
.
The three new genes related to FMD are ATP2B1, LRP1 and LIMA1, and the fourth gene that has been confirmed is PHACTR1

"This is the most comprehensive genetic survey of foot-and-mouth disease so far, and it was made possible through the joint efforts of our international research team," Ganesh pointed out

Paper citation:

 "Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases,"Nature Communications .