New therapeutic targets could stop the progression of Alzheimer's disease

UMA scientist Inés Moreno, in collaboration with the University of Texas, conducted a new study that found a potentially non-invasive therapy that could stop the progression of Alzheimer's disease, "the dominant form of dementia in the elderly population
.

Researchers at the University of Malaga have succeeded in reducing the amount of toxic proteins in the brain — proteins that clump together — in a preclinical model — the leading cause
of death in Alzheimer's neurons.

balance

These proteins are also present in the blood, and according to UMA experts, they are in equilibrium with the brain — if they increase in the brain, they also increase in the blood, and vice versa
.

The researchers at the UMA group "NeuroAD" explain: "Clearing toxic proteins from the brain is the goal
of most current Alzheimer's disease therapies.

Act at the cyclic level

What's innovative about this study is that it proposes to reduce these toxins in the blood because they are also present in the
blood.

The scientist notes that blood sample analysis is now being used in some cases to diagnose diseases as an alternative to
neural images.

In this way, the results validated in animal models have shown that this treatment can improve memory and learning ability, correct cognitive impairment, not only remove toxic proteins, but also change the key factors
in the development of the disease.

Next: Establish a clinical model

Inés Moreno is an associate professor at the University of Texas, which will continue the study at the clinical level, seeking to determine the molecular mechanisms associated with disease improvement and whether it can work
for patients through dialysis or even blood transfusions for patients with dementia.