New supplier SPI—advantageous supplier of excipients such as mannitol and sorbitol sorbitan solution

SPI product introduction

D50: 125μm Bulk density: 0.

Features: spray drying model

Mannogem ^®XL Ruby

D50: 300μm NF/EP/JP

Features: First both tablet size and pleasant feelings taking granular mannitol (can be made smaller in the film), it is particularly suitable for use in the elderly and children taking larger size oral tablets , to improve patient compliance And taking medicine experience

It has excellent compressibility, better content uniformity, softer texture and faster disintegration speed, and its performance meets and exceeds the requirements of the pharmacopoeia

Mannogem ^®  XL Opal

D50: 160μm

Features: It is a product made by SPI with its unique technology and process.

Mannog em ^®  Granular/2080

D50: 320μm Bulk density: 0.

Features: The surface is net-like, which can make the API powder adsorb on the surface, which can achieve a good mixing effect; low moisture absorption, suitable for the use of moisture-sensitive API

Mannoge m ^®  EZ

D50: 125μm Bulk density: 0.

Features: spray drying model

USP/EP, the new species included in the 2020 edition of the Pharmacopoeia, will be introduced separately in later articles

Features: 20-30% dosage in soft capsules
.
This product is a soft gel plasticizer based on sorbitol treatment
.
Its excellent plasticizing effect can greatly shorten the drying time of the second step of soft capsules; soft capsules with PEG as the content, using this product as a plasticizer will not cause migration, which can prevent soft capsules from blooming
.
Among them, MDF85 provides a glossier and stronger soft capsule than other grades of plasticizers, which is especially suitable for ibuprofen soft capsules
.
There is no need to add glycerin when using A-810
.
The soft candy refined with this product has also been proven to withstand the higher pressure of viscous or semi-solid filling preparations without deformation
.

Pharmaburst ^®  500

D50: 130μm Bulk density: 0.
437g/ml

Features: It can be seen from the electron micrograph that the composite auxiliary material is a product with a certain porosity composed of fragments of different sizes connected together, which has a good cushioning effect during compression
.
The excellent compressibility and fluidity of Pharmaburst ^® 500 make it widely used in orally disintegrating tablets
.
Orally disintegrating tablets made with this product have many advantages: smooth and clean appearance, good taste, disintegration time limit, high hardness, low friability, and it has been used in risperidone, ondansetron, alprazolam, etc.
60 Used in multiple marketed formulations
.

Effer-Soda ^® 

Features: Special sodium bicarbonate modified into sodium carbonate on the surface.
The product has stable properties and can well solve the industry pain point of effervescent tablets-carbon dioxide generated by moisture absorption reaction and stickiness problems
.
This product makes it easier to develop and produce many pharmaceutical products, so it has been widely used in effervescent powders and effervescent tablets such as multivitamins, analgesics and cough/cold medicines
.

This product can change the pH of the microenvironment and affect the dissolution and release of the drug.
It is especially suitable for pharmaceutical preparations that need to be released in a slightly alkaline environment.
For example, this product has been widely used in cefixime antibiotics, paracetamol quick-acting tablets, and rebamipide , Rabeprazole and other products
.

Introduction to SPI

SPI Pharma in the United States is a subsidiary of ABFI.
ABFI is a multi-billion-dollar multinational company with operations all over the world
.
SPI focuses on the pharmaceutical market, ensuring that its products are of first-class quality and providing excellent services by meeting or exceeding the requirements of national laws and regulations
.
All SPI products are produced in factories that comply with cGMP standards and are mainly used in solid formulations, suspensions, effervescent tablets, chewable/fast disintegrating tablets, orally disintegrating tablets and granules
.