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A new study in mice shows exactly how triclosan, an antibacterial substance found in toothpaste, toys and thousands of other products, triggers intestinal inflammation
.
An international team of researchers led by the University of North Carolina at Chapel Hill, the University of Massachusetts Amherst and Hong Kong Baptist University found the trigger.
Triclosan harmfully affects bacteria and even specific enzymes
.
In addition, studies in mice have shown that these bacterial enzymes can be blocked from causing intestinal damage
The findings, published in the journal Nature Communications, are titled "Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract
.
"
"By identifying the culprit bacteria, new ways of diagnosing, preventing and treating inflammatory bowel disease could be developed," said study author Matthew Redinbo, chemistry and chemist at UNC-Chapel Hill College of Arts and Sciences and UNC School of Medicine.
Professor of Microbiology
.
Previous studies have shown the toxicity of triclosan, but the new study provides a closer look at changes in gut microbial populations
.
The researchers linked specific gut microbial enzymes, specifically the gut microbial beta-glucuronidase (GUS) protein, to triclosan and showed that these enzymes drive triclosan to wreak havoc in the gut
.
After knowing which bacterial proteins were to blame, the team used a microbiota-targeted inhibitor to block the effects of triclosan in the gut
.
Blocking this process in mice prevented damage to the colon and symptoms of colitis, an inflammatory bowel disease
This study provides new clues for more and more IBD patients to treat IBD
.
IBD can be managed for an extended period of time and just flare up seemingly out of nowhere
The study authors suggest that a better understanding of the impact of environmental chemicals on gut health is needed
.
Triclosan was widely used in antibacterial soaps sold to consumers
.
But in 2016, the Food and Drug Administration ordered it removed from handwashing products used in homes and hospitals over concerns it could lead to more drug-resistant bacteria
But triclosan remains ubiquitous as an ingredient added to makeup, yoga mats and other sportswear and gear to reduce bacterial contamination
.
Approved by the U.
Triclosan appears to be readily absorbed from the gastrointestinal tract, and the study's lead author wrote: "Considering the potential damage to the gut from triclosan and related compounds, their safety profile should be reconsidered
.
"
Magazine
Nature Communications
DOI
10.
