New study reveals tumor cell 'sleep" mechanism
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Last Update: 2020-06-03
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Source: Internet
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Author: User
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Cancer cells usually migrate and are hidden in other parts of the body to remain inactiveThese cells can be reactivated at any time and pose a serious risk of relapse and metastatic diseasesOnce the disease spreads, the likelihood of cure for cancer is greatly reducedSo far, there is still insufficient understanding of tumor sleepIdentification and killing of inactive tumor cells remains a major problem in cancer treatmentcell aging has long been understood as a DNA damage response in which normal cells stop dividing;Studies led by Gewirtz and recently published in biochemical pharmacology have shown that breast and lung cancer cells with an aging state caused by chemotherapy can eventually recover and remultiply quickly in culture and miceThe findings challenge the general idea of aging cancer cellsbased on these findings, Gewirtz, in an article published in Cancer Research, suggests that senescent cells are important in further research aimed at better understanding how tumor cells evade existing cancer treatments and hide in dormant states, and to inform the development of new cancer treatments"If aging is a form of tumor sleep, then tumor cells that escape aging and survival will in some cases become a source of recurrent diseasesTheir elimination will provide a survival advantage for cancer patients," Gewirtz added.
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