New study investigates the effect of ORi-guided oxygen titration on hyperoxia-mediated lesions during one-lung ventilation

Masimo(NASDAQ: MASI) today released the results of a study published in the Turkish Journal of Medical Sciences .

ORi was launched outside the United States in 2014 and is a non-invasive continuous parameter designed to further understand the oxygen status of patients during supplemental oxygen

The researchers pointed out that OLV is a commonly used technique to simplify various lung operations, and 100% fractional oxygen intake (FiO ₂ ) is commonly used to supplement oxygen, which exposes patients to the possibility of hyperoxia-induced lung injury, so they seek to determine ORi Is it possible to "use non-invasive probes during OLV to protect patients from the harmful effects of hyperoxemia"

Grouping

Number of subjects

OLV duration when FiO ₂> 60%

FiO ₂ average

25

67.

71.

28

97.

74.
64 ± 16.
66%

3: Oxygen titration with ORi, low airflow anesthesia (1L/min)

25

39.
2 ± 74.
1 minutes

62.
8 ± 13.
08%

4: Oxygen titration with ORi, high airflow anesthesia (4 L/min)

25

22.
4 ± 49.
4 minutes

56.
4 ± 11.
5%

Grouping

Number of subjects

OLV duration when FiO ₂> 60%

FiO ₂ average

Grouping

Grouping

Number of subjects

Number of subjects

OLV duration when FiO ₂> 60%

OLV duration when FiO ₂> 60%

FiO ₂ average

FiO ₂ average

1: Oxygen titration without ORi, low airflow anesthesia (1L/min)

25

67.
6 ± 97.
5 minutes

71.
6 ± 12.
25%

1: Oxygen titration without ORi, low airflow anesthesia (1L/min)

1: Oxygen titration without ORi, low airflow anesthesia (1L/min)

25

25

67.
6 ± 97.
5 minutes

67.
6 ± 97.
5 minutes

71.
6 ± 12.
25%

71.
6 ± 12.
25%

2: Oxygen titration without ORi, high airflow anesthesia (4 L/min)

28

97.
32 ± 99.
7 minutes

74.
64 ± 16.
66%

2: Oxygen titration without ORi, high airflow anesthesia (4 L/min)

2: Oxygen titration without ORi, high airflow anesthesia (4 L/min)

28

28

97.
32 ± 99.
7 minutes

97.
32 ± 99.
7 minutes

74.
64 ± 16.
66%

74.
64 ± 16.
66%

3: Oxygen titration with ORi, low airflow anesthesia (1L/min)

25

39.
2 ± 74.
1 minutes

62.
8 ± 13.
08%

3: Oxygen titration with ORi, low airflow anesthesia (1L/min)

3: Oxygen titration with ORi, low airflow anesthesia (1L/min)

25

25

39.
2 ± 74.
1 minutes

39.
2 ± 74.
1 minutes

62.
8 ± 13.
08%

62.
8 ± 13.
08%

4: Oxygen titration with ORi, high airflow anesthesia (4 L/min)

25

22.
4 ± 49.
4 minutes

56.
4 ± 11.
5%

4: Oxygen titration with ORi, high airflow anesthesia (4 L/min)

4: Oxygen titration with ORi, high airflow anesthesia (4 L/min)

25

25

22.
4 ± 49.
4 minutes

22.
4 ± 49.
4 minutes

56.
4 ± 11.
5%

56.
4 ± 11.
5%

During OLV, patients in groups 1 and 2 undergo oxygen titration without ORi, while groups 3 and 4 use ORi from Masimo Radical-7 ^® Pulse Carbon Oxygen-Oxygen Saturation Meter ^® and rainbow ^® sensors
.
For all four groups, SpO ₂ and arterial partial pressure of oxygen (PaO ₂ ) were routinely measured , while FiO ₂ was routinely administered 50% after induction, increased to 60% when OLV was applied, and increased to 70%-100% as needed
.

The researchers found that the results related to ORi monitoring include: a significant reduction in OLV duration when FiO ₂  > 60%, a significant decrease in the average FiO ₂ during OLV (as shown in the table above), and a lower PaO ₂ record value
.
They also found that the duration of FiO ₂  > 80% during OLV was strongly correlated with longer hospital stays (p <0.
001)
.

Compared with the ORi-free group (1 and 2), the observation that the ORi group (3 and 4) has a significantly lower average FiO ₂ makes the researchers hypothesize that "the risk of hyperoxia for patients monitored by ORi will be reduced.
"
.
The researchers pointed out: "ORi is not a substitute for arterial blood gas analysis; but it is useful for assessing oxygenation
.
In the group without ORi monitors, FiO ₂ was significantly higher than 80%
.
In addition, this study found that the above patients had a longer hospital stay
.
"

There was no significant difference between the ORi values ​​of low-flow (group 3) and high-flow (group 4) queues
.

The researchers concluded: “ORi adjusted by peripheral oxygen saturation and blood gas analysis showed that hyperoxemia during OLV in patients with low or high flow anesthesia can be prevented
.
Our conclusion is that thoracic anesthesia under the guidance of ORi may be possible Shorten hospital stay and improve patient safety
.
"

ORi has not yet been approved by the FDA and has not been marketed in the United States
.

@Masimo  | #Masimo

About Masimo

Masimo (NASDAQ: MASI) is a global medical technology company that develops and produces a wide range of industry-leading monitoring technologies, including innovative measurement equipment, sensors, patient monitors, automation and intercommunication solutions
.
Our mission is to improve patient outcomes, reduce treatment costs, and deliver non-invasive monitoring to new scenarios and applications
.
In 1995, the company launched the Masimo SET ^® Measure-through Motion and Low Perfusion™ pulse oximeter.
More than 100 independent and objective studies have shown that its performance is superior to other pulse oximeter technologies ²
.
Studies have shown, the SET Masimo ^® can help clinicians reduce preterm neonates with severe retinopathy ³ , CCHD improve newborn screening ⁴ , continuous monitoring of Masimo Patient SafetyNet ™ for postoperative ward, can reduce the Rapid Response Team mobilized , ICU transfer and cost ^5-8
.
Masimo SET ^® is estimated to have been applied to more than 200 million patients in leading hospitals and other medical institutions around the world ⁹ , and is among the top 10 hospitals in the top 10 hospitals in the U.
S.
News and World Report 2020-21 The main pulse oximeter used ¹⁰
.
Masimo continues to optimize SET ^® and announced in 2018 that SpO ₂ on the RD SET ^® sensor in a mobile stateThe accuracy has been significantly improved, making clinicians more confident that the SpO ₂ value they rely on accurately reflects the physiological state of the patient
.
In 2005, Masimo launched the rainbow ^® pulse carbon oxygen-oxygen saturation meter technology, which realized the non-invasive continuous monitoring of blood components that could only be invasively measured in the past, including total hemoglobin (SpHb ^® ), oxygen content (SpOC™), carbon Oxyhemoglobin (SpCO ^® ), methemoglobin (SpMet ^® ), pulse perfusion variability index (PVi ^® ), RPVi™ (rainbow ^®  PVi), oxygen reserve index (ORi™)
.
In 2013, Masimo launched the Root ^® patient monitoring and intercommunication platform, which was designed from the ground up to be as flexible and scalable as possible in order to add other Masimo and third-party monitoring technologies
.
Key Masimo additions include the next-generation SedLine ^® brain function monitor, O3 ^® local oxygen saturation meter, and ISA™ carbon dioxide analyzer with NomoLine ^® sampling cable
.
Masimo's continuous and spot-inspection monitors Pulse Carbon Oxygen-Oxygen Saturation ^Meter® family includes devices designed for use in various clinical and non-clinical applications, including wireless wearable technologies (such as Radius- ^7® and Radius PPG™), Portable devices (e.
g.
Rad-67^® ), fingertip pulse oximeter (such as MightySat ^® Rx), hospital and home dual-use equipment (such as Rad-97 ^® )
.
Masimo hospital automation and intercommunication solutions are centered on Masimo Hospital Automation™ platform, including Iris ^®  Gateway, iSirona™, Patient SafetyNet, Replica™, Halo ION™, UniView ^® , UniView:60™, Masimo SafetyNet™
.
For more information about Masimo and its products, please visit style="vertical-align: inherit;"> .
For published clinical studies of Masimo products, please visit style="vertical-align: inherit;"> .
  

ORi and RPVi have not obtained FDA 510(k) certification and are not marketed in the United States
.
The Patient SafetyNet trademark is used under license from the University HealthSystem Consortium
.
  

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