New study identifies genes involved in glioblastoma cell development

A research paper recently published in Nature Communications by a team led by researchers at the Yale University School of Medicine has found a promising way to make brain cancer cells more susceptible to chemothera.

Glioblastoma is the most common malignancy of the brain and central nervous system, accounting for almost half of all cas.

In a paper titled "ZNF117 regulates the differentiation of glioblastoma stem cells to the oligodendrocyte lineage" published in Nature Communications, the researchers discovered a method that triggers the maturation of glioblastoma stem cells into cancer Cell-based approach, which can kill cancer cells with drugs such as temozolomi.

The researchers first developed a new technique to identify all the genes that trigger glioblastoma stem cells to develop into mature cancer cel.

The researchers found that the ZNF117 gene is a major regulator of tumor cells, which can develop into oligodendrocyte-like tumors through screeni.

These findings were initially discovered in vitro, but were confirmed by mouse mode.

"Brain cancer treatments have limited efficacy," said first author Jianbing Zhou, .

While it may take many years to translate these findings into drugs, the findings could be combined with CRISPR technology, a therapy for gene editing that could make chemotherapy more effective, .

"The work described in this paper represents many years of steady and creative work," said Mark Saltzman, Goizueta Foundation Professor of Biomedical Engineering, Chemical and Environmental Engineering, and Physiology in the Yale School of Engineering and Applied Sciences, who also contributed to the pap.