New study finds genetic pattern of familial Alzheimer's disease in China

　　MEDICINE NETWORK JANUARY 15 ( XINHUA) -- PROFESSOR JIA JIANPING'S TEAM AT XUANWU HOSPITAL IN BEIJING RECENTLY PUBLISHED A STUDY ONLINE IN THE JOURNAL ALZHEIMER'S DISEASE AND ALZHEIMER'S DISEASE The study, which followed 404 Chinese family Alzheimer's disease (FAD) families for 17 years, systematically revealed the genetic patterns of the disease and provided a theoretical basis for genetic intervention and gene therapy for Alzheimer's disease (AD) in China it is known that FAD is very rare, but it concentrates all the pathological physiological characteristics of Alzheimer's disease, becoming the best person to study the pathogenesis of the disease Since the first case of Alzheimer's disease was reported in 1906, important advances in pathogenesis such as A-beta, tau, and inflammation have come from FAD research Therefore, the researchers suggest that Alzheimer's disease research should start with FAD Jia Jianping team began in 2002 to establish the country's largest family Alzheimer's disease registration network, nationwide collection of FAD cases As of September 2019, a total of 404 family families and more than 3,700 family members had been collected The study found 50 PSEN/APP mutations, 11 of which were first reported internationally, indicating the heterogeneity of the pathogenesis between Chinese and other races 83.17% of the 404 family lines do not carry the known gene PSEN/APP mutation, and there are still a large number of unknown genes to be excavated, which will be important for the discovery of the genes that Chinese Alzheimer's disease this study has an important impact on understanding the pathogenesis of Chinese Alzheimer's disease, and also provides a platform for the genetic intervention and gene therapy of Alzheimer's disease in China, which is expected to start from the editorial aspect, reverse genetic defects, and find new breakthroughs for the eventual cure of Alzheimer's disease.