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Prof.
Nikolai Kuhnert and his team were able to demonstrate that a compound in coffee inhibits the interaction
between the spike protein and the ACE-2 receptor.
(Source: Jacobs University)
Is drinking a cup of coffee effective in protecting yourself from coronavirus? According to biochemical research, what has not yet been proven in practice is at least very plausible: the team led by chemist Professor Nikolai Kuhnert, including Dorothea Schmidt and Nicholas Ohl of Jacobs University, was able to experimentally demonstrate in the laboratory that the compound 5-caffeoylquinic acid (the name is simple: chlorogenic acid), found in coffee, inhibits the SARS CoV-2 spike protein of the coronavirus with the ACE-2 receptor (docking points of viruses on human cells) with up to 50-fold
inhibition.
A regular cup of filtered coffee—which in a lab setting, contains exactly 200 milliliters—contains about 100 milligrams of 5-caffeoylquinic acid
.
Laboratory experiments have shown that this concentration of 5-caffeoylquinic acid is high enough to block the docking of the spike protein with the ACE-2 receptor and therefore also inhibit the infectious process
.
Further research
is needed to prove that this process also works in practice.
Further research is needed to determine how long
the inhibitory effect of 5-caffeoylquinic acid lasts.
"As chemists, we can't answer the practical question
of whether drinking coffee can really be used as a measure to prevent infection.
But we can say that it is reasonable
.
"Many people drink coffee, it has many other positive effects, which are well known
," said the chemist.
For example, people who drink coffee regularly have a lower chance of developing type 2 diabetes, and the scientific evidence for this is abundant, he notes
.
To study the effects of 5-caffeoylquinic acid on the spike protein and ACE-2 receptors, the team led by Nikolai Kuhnert had to develop a new measurement technique: differential scanning fluorescence or nano-DSF
.
As a next step, the findings about the interaction between coffee and coronavirus will now be communicated to researchers in psychology and social sciences: "Epidemiological studies can determine whether people who drink coffee regularly are more often infected with coronavirus," says
Nikolai Kunate.
This article will also introduce the background and impact of
the long crown epidemic.
“
