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The latest research by an international team of researchers shows that in addition to risk factors such as age, sex, and whether or not you have underlying disease, a common variant of a gene carrying is also associated
with the risk of COVID-19 death.
with the risk of COVID-19 death.
An international research team led by Rockefeller University in the United States recently published a paper in the British journal Nature that said that mice have a higher risk of death after infection with new crown when carrying certain variants responsible for encoding apolipoprotein E genes; Their retrospective analysis also showed that humans who carried these genetic variants were also at higher
risk of dying from COVID-19 infection.
risk of dying from COVID-19 infection.
Apolipoprotein E is one of the most abundant proteins in the human brain, and several alleles exist in the genes responsible for encoding this protein, of which the apolipoprotein E3 allele is the most common, while about 40% of people carry at least one copy
of the apolipoprotein E2 or E4 allele.
The apolipoprotein E encoded by different alleles may differ by only a few amino acids, but these subtle differences have consequences
that cannot be underestimated.
of the apolipoprotein E2 or E4 allele.
The apolipoprotein E encoded by different alleles may differ by only a few amino acids, but these subtle differences have consequences
that cannot be underestimated.
The team genetically engineered more than 300 mice to carry different human apolipoprotein E alleles, exposing them to a new coronavirus capable of
infecting mice.
The results showed that mice carrying the E4 and E2 alleles were more likely to die than mice carrying E3 alleles, and there was more viral replication in the lungs and more signs of inflammation and tissue damage in
the body.
infecting mice.
The results showed that mice carrying the E4 and E2 alleles were more likely to die than mice carrying E3 alleles, and there was more viral replication in the lungs and more signs of inflammation and tissue damage in
the body.
In a subsequent retrospective study, they analyzed data
from 13,000 COVID-19 patients at the UK Biomedical Bank.
It was found that people who carried two copies of the E4 or two copies of the E2 allele were more
likely to die from COVID-19 than those who carried two copies of the E3 allele.
About 3% of the world's population carries two copies
of the E4 or E2 allele.
from 13,000 COVID-19 patients at the UK Biomedical Bank.
It was found that people who carried two copies of the E4 or two copies of the E2 allele were more
likely to die from COVID-19 than those who carried two copies of the E3 allele.
About 3% of the world's population carries two copies
of the E4 or E2 allele.
But the researchers also say there is no evidence that people who carry only one copy of the apolipoprotein E2 or E4 allele have an increased
risk of dying from COVID-19 infection.
In addition, even people with two copies of the E2 or E4 allele may now have a lower risk of dying from COVID-19 infection due to continued vaccination with the COVID-19 vaccine
.
risk of dying from COVID-19 infection.
In addition, even people with two copies of the E2 or E4 allele may now have a lower risk of dying from COVID-19 infection due to continued vaccination with the COVID-19 vaccine
.
If future studies further confirm the link between the apolipoprotein E gene and the COVID-19 outcome, clinicians may prioritize vaccination, immunization, and antiviral therapy
for people carrying the apolipoprotein E4 or E2 alleles, the researchers said.
for people carrying the apolipoprotein E4 or E2 alleles, the researchers said.
