New strategies to kill leukemia cells have been found

Reporters from Xi'an Jiao university second affiliated hospital biological diagnosis and treatment of the National Joint Engineering Research Center was informed that the center's team of Professor Kong Guangyao found a new strategy that can kill bone marrow proliferation tumor cells, or will bring good news for the treatment of patients with myeloid leukemia.Professor
Kong Guangyao's team recently published online the study entitled
"Reducing the Notch signaling path in bone marrow-proliferating tumors can counteract the activation of ERK signaling paths and oxidation phosphate caused by Kras
mutants" online in the leading journal in the field of leukemia. The study showed that, unlike acute myeloid leukemia, notch signaling paths play a major role in cancer genes in bone marrow-proliferating tumors. Further mechanism studies have found that inhibiting the Notch signaling path can inhibit the activation of the ERK signaling path, as well as the oxidation phosphorylation of leukemia cells. More importantly, inhibiting both ERK signaling path and phosphorylation has a better targeted killing effect on leukemia cells, which may be a new strategy for bone marrow proliferation tumor targeting therapy.
, leukemia ranks 6th (male) and 8th (female) in the mortality rate of malignant tumors in China, and 1st among children and adults under 35 years of age. Kong Guangyao said that bone marrow proliferation tumor is a kind of malignant blood tumor originating from hematopoietic stem cells, there is no effective targeted treatment strategy. The researchers found that Notch signaling paths were involved in the development of multiple tumors, but their role in different tumors was significantly tissue-specific and environmentally dependent. Previous studies have shown that notch signaling paths play a role in anti-cancer genes in acute myeloid leukemia. (Source: Xinhua News Agency