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New spontaneous mouse model is expected to support the treatment of Sjogren's syndrome

 Last Update: 2021-09-04
 Source: Internet
 Author: User

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Professor Tetsuya Kodama of the Cancer Biomedical Engineering Laboratory of the Graduate School of Biomedical Engineering, Tohoku University, Japan, led a research team and reported how McH-lpr/lpr-RA1 (McH/lpr-RA1) mice can be used as Sj?gren syndrome animals Model

McH/lpr-RA1 mice are inbred mice

Kodama, Mori and Dr.

Further observation of McH/lpr-RA1 mice found extensive infiltration of inflammatory cells (mainly lymphocytes) in the salivary gland tissue and destruction of the existing salivary gland structure

Aquaporin 5 is a key protein for the production and secretion of saliva.

The research team hopes that the relationship between Sjögren syndrome and malignant lymphoma can be studied in model mice, because vasculitis is associated with the development of malignant lymphoma in patients with this disease

Kodama believes that, compared with other model mice, McH/lpr-RA1 mice are a better disease model for autoimmune sialadenitis because they do not develop nephritis and live longer

McH/lpr-RA1 mice are now registered at the Riken Biological Resource Center in Tsukuba, Japan (BRC No.

Journal Reference :

Keiichi Saito, Shiro Mori, Tetsuya Kodama.

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