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Muscular dystrophy is a debilitating disease that causes skeletal muscle to weaken and break down, which gets progressively worse over time
Due to the molecular similarities between zebrafish and human muscles, zebrafish is a valid test model for muscular dystrophy
However, zebrafish can't lift heavy objects, so researchers at Umaine University used a method called neuromuscular electrical stimulation (NMES), which stimulates specific nerves to cause muscle contractions
The study found that while each NMES weightlifting "routine" had different effects on zebrafish neuromuscular connection morphology, swimming, and survival, only one -- endurance neuromuscular stimulation (eNMES) -- provided certain antioxidants, Heme oxygenase and a receptor called integrin alpha 7, all three are improved
“Utilization is defined as high-frequency, low-voltage pulses, which are similar to a session, lightweight workout we would do in the gym
The study was published March 24, 2022 in the journal ELife
This study suggests that proper resistance training may benefit people with muscular dystrophy
"I think the most exciting aspect is that we have modeled neuromuscular plasticity in healthy versus diseased muscle, and this model will allow us to elucidate mechanisms that may underlie potential future treatments
article title
Beneficial impacts of neuromuscular electrical stimulation on muscle structure and function in the zebrafish model of Duchenne muscular dystrophy
