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Written byWang Cong
EditorWang Duoyu
TypesettingWater into text
responsible for pneumonia.
Chlamydia pneumoniae mainly infects the lung and nasal mucosa, but studies in recent years have found that it has been linked to a variety of diseases other than the respiratory tract, such as atherosclerosis/coronary artery disease, asthma, inflammatory arthritis, multiple sclerosis, and late-onset dementia (late-onset Alzheimer's disease
).
In recent years, many studies have shown the presence of Chlamydia pneumoniae DNA in the brains of late-onset Alzheimer's patients, and even the detection of live Chlamydia pneumoniae, and the association between central nervous system infection by Chlamydia pneumoniae and late-onset dementia has become increasingly obvious
.
Recently, researchers from Griffith University in Australia published a paper in the journal Scientific Reports title: Chlamydia pneumoniae Can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer's disease risk
.
The study showed that inoculation of the nasal mucosa of mice with Chlamydia pneumoniae could infect the olfactory nerve, trigeminal nerve, olfactory bulb, and brain
within 72 hours.
At 7 and 28 days after vaccination, infection with Chlamydia pneumoniae leads to disruption of key pathways in the onset of Alzheimer's disease, leading to β-amyloid (Aβ) accumulation
.
In vitro experiments have shown that Chlamydia pneumoniae is capable of infecting peripheral nerves and central glial cells
.
This study shows that the nerves between the nasal cavity and the brain constitute the pathway for Chlamydia pneumoniae to rapidly invade the central nervous system, and that pneumoniae bacilli may survive in the glia after infection and cause Aβ deposition, thereby promoting the development and progression
of Alzheimer's disease.
This study suggests that Chlamydia pneumoniae invades the central nervous system
using the nerves between the nasal cavity and the brain as an invasion pathway.
Brain cells then respond by depositing β-amyloid (Aβ), β a biomarker of Alzheimer's disease
.
Professor James St John, co-author of the paper, said this is the first time that Chlamydia pneumoniae can enter the brain directly through the nose and cause Alzheimer's disease-like lesions in the brain, which has been observed in mouse models.
These findings and evidence can also be frightening
for humans.
Chlamydia pneumoniae (green) inside the mouse brain, surrounded by β-amyloid (red)
olfactory nerves in the nasal cavity are exposed directly to the air, providing a pathway
around the blood-brain barrier into the brain.
This has also become a shortcut for viruses and bacteria to enter the brain
.
The research team said that the next phase of research is already being planned, aiming to prove that the same path
exists in humans.
It is known that Chlamydia pneumoniae is also present in humans, but it is not yet known how they got there
.
Professor James St John said that if you want to reduce your risk of Alzheimer's disease, there are some simple steps you can take now to take care of your nasal mucosa, and picking your nose and pulling out your nose hair can damage the nasal mucosa, thereby increasing the amount of these bacteria entering the
brain 。 After age 65, the risk of Alzheimer's disease rises rapidly, and age may not be the only factor, environmental exposure is also important, and bacteria and viruses may be the key
.
It is worth mentioning that recently, the team of Associate Professor Chen Hong of Washington University in St.
Louis published a publication in the eBioMedicine journal entitled : Incisionless targeted adeno-associated viral vector delivery to the brain by focused ultrasound-mediated intranasal administration research paper [2].
。
The study, which validates the team's previously developed focused ultrasound intranasal delivery (FUSIN) method in a mouse model for the first time, confirms that FUSIN is able to break through the blood-brain barrier (BBB) and convert adeno-associated viral vectors (AAV) is efficiently delivered to the brain
through the nose.
This delivery efficiency works better than other delivery methods and has minimal
impact on other organs in the body.
This study suggests that bypassing the blood-brain barrier through the nose may lead to better gene therapy delivery routes to treat central nervous system diseases such as brain tumors and neurodegenerative diseases
Links to papers: style="color: rgb(136, 136, 136);font-family: system-ui, -apple-system, BlinkMacSystemFont, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;font-size: 12px;letter-spacing: 0.
544px;text-align: left;background-color: rgb(255, 255, 255);" _mstmutation="1" _istranslated="1">https://doi.
org/10.
1016/j.
ebiom.
2022.
104277
Open reprint welcome to forward to Moments and WeChat groups
