New research reveals the molecular mechanisms that cause vascular stenosis in diabetes

blood vessel stenosis is one of the main complications of diabetes and increases the risk of diseases such as heart disease and stroke. A new U.S. study says the molecular mechanisms that cause vascular stenosis caused by diabetes have been discovered, which could help develop precise diabetes-targeted drugs.
team at the University of California, Davis, has previously found that high blood sugar activates an enzyme in the body called protein kinase A, which increases calcium channel activity and constricts blood vessels.
to understand the molecular mechanisms, the team built a model of diabetic mice that focused on the relationship between protein kinase A and adenosine cyclase (AC). Adenosine cycloase is an enzyme involved in the synthesis of cyclosides, a messenger substance that is critical to the function of blood vessel cells.In a paper published in the American Journal of Clinical Examinations, the
team said the latest animal results show that AC5, a specific type of adenosine cyclase, is critical for blood vessel contractions in diabetic patients, regulating protein kinase A and cyclosideside activity, triggering increased calcium channel activity and vascular contraction."Our study raises a clearer picture of how high blood sugar damages the vascular system and provides us with a target to stop this effect," said
co-author Roger Tetrian, a professor at the University of California, Davis. As
next step, the team plans to verify the "chain reaction" of AC5 in human cells under high blood sugar conditions. (Source: Xinhua News Agency)
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