New research has found that two human genes are linked to bird flu

A team of researchers at the University of Chicago in the United States found that the H5N1 avian influenza virus infects human pulmonary endotment cells in a mechanism linked to two human genes, so new antiviral methods can be developed by affecting both genes.
related papers published in the new issue of the American academic journal
10th. When the H5N1 avian influenza virus infects the body, it is often invaded by pulmonary corted cells, the researchers said. To screen which genes are linked to the mechanism of viral infection, the researchers used gene editing techniques to create about 1. There are 90,000 lung corted cells with different genetic variants that exposed them to the H5N1 virus.
found that a gene called SLC35A1 is responsible for encoding a subject on the cell surface that the virus can use to "land" on the cell surface. If it is knocked out, the virus loses its infected host's grip.
another gene called CIC regulates the immune response, which inhibits the immune response of cells to foreign pathogens. If it is turned off, the immune response will be stronger and help fight the avian influenza virus.
But baraj Manikasami, an assistant professor of microbiology at the University of Chicago and one of the authors of the paper, said the CIC gene cannot be permanently removed to fight the virus because it is needed to shut down the immune response after the infection, which can lead to autoimmune diseases.
researchers say the findings could help develop new ways to help the body fight the bird flu virus. In addition, they used similar methods to expos cells to other pathogens, and found that the CIC gene played an important role in a variety of diseases and could therefore be targeted in the treatment of a variety of diseases. (Source: Xinhua News Agency Zhou Zhou)